Apheresis Red Cell Technology

1
Apheresis Red Cell Technology

• Strategy for Increasing the Blood Supply

2
National Blood Exchange - Supply and Demand
Units requested Units listed
Fall
Winter
25,000
20,000
15,000
Number of Units
10,000
5,000
1990-91
1989-90
1991-92
1992-93
1993-94
1994-95
1995-96
1996-97
1997-98
1989-90
1990-91
1991-92
1992-93
1993-94
1994-95
1995-96
1996-97
1997-98
Year
Year
Source AABB News, March 1999
3
U.S. Blood Donation DeclineNational Blood Data
Resource Center
Blood Supply ?, Transfusions ? By year 2000 the
blood supply will ? by 600,000 units. This is
249,000 units lt expected need Blood supply
trend Units Transfused1992 - 11.3 million
transfusion1997 - 11.5 million
transfusions Units Collected 1992 - 13.2 million
donations 1994 - 12.9 million donations 1997 -
12.3 million donations
4
Red Cell Apheresis Protocols

• Two-Units of Red Cells
• Red Blood Cells and Plasma
• From 1 donation

5
Apheresis Red Cell FDA Clearance History
April 1998 First 2-RBC Blood Bank
License 1997 510(k) clearance for Allogeneic
2-RBC 1996 510(k) clearance for Autologous
2-RBC 1995 510(k) clearance for Allogeneic /
Autologous RBC Plasma
6
2RBC Allogeneic Nomogram

• Males
• 130 pounds
• 51 height
• 40 hematocrit
• 112 day deferral

• Females
• 150 pounds
• 55 height
• 40 hematocrit
• 112 day deferral

RBCP nomogram is the same as whole blood.
7
Worldwide Apheresis Red Cell Growth
Actual data annualized.
8
2RBC Conversion Strategy Group O B Donors
962,000 more RBC Products (Early) (8) 1,620,000
more RBC Products (Mature) (14) Assumption 12
Million WB Donations. 70 Mobile.
9
Face-to-Face Conversion Success

• Whole Blood to Apheresis Collection through
  face-to-face conversion.
• No telerecruitment used
• Approximately 50 increase in 2RBC procedures
  from April to June
• Approximately 21 increase in RBCP procedures
  from April to June

Procedures
10
Apheresis Red Cell Leukoreduction

• Europe in-line leukoreduction since 1996.
• Domestic 2RBC in-line leukoreduction in clinical
  trials.

11
Economics

• Recently Haemonetics and an economics consulting
  firm collected data from 15 blood centers across
  the United States pertaining to whole blood
  collections.
• Study conclusion of 15 Blood Centers
• clear cut advantage in replacing certain whole
  blood collections.

12
Conclusion

• Apheresis Red Cell Technology