Clinical Summary Lung Cancer In Women

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Clinical SummaryLung Cancer In Women
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• 85 of pts with lung cancer have smoked. Only
  20 of patients who smoke get cancer
• The incidence of smoking in women is rising.
• The incidence of lung cancer in women is
  expected to continue to rise
• Mechanisms for increased risk in women
• Behavioral More tar, nicotine, toxins.
  Addiction- MHC haplotype chromosome 6
• Metabolic 2 pathways detox or activation.
  DNA adduct levels higher in women
• Hormonal CYP1A levels adversely
  influenced by estrogen
  Early menarche, late menopause, HRT increases
  risk Genetic Genetic mutation P53 tumor
  suppressor gene HAP, K-ras oncogene
• over-expression
• Evidence shows that women who develop lung
  cancer do so
• At an earlier age
• After lower smoking exposures or non-smoking than
  men
• More adenocarcinoma and broncho-alveolar
  carcinoma than men
• Are diagnosed at later clinical stage of disease
  than men
• Survive surgery better than men
• Experience greater toxicities from chemotherapy
  than men, but
• Better survival, live longer with lung cancer
  than men