Mayo Clinic Genomic Education Program. Dr. David B

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Mayo Clinic Genomic Education Program
Dr. David B. Schowalter Assistant Professor, Dept
Medical Genetics Genomics Education Steering
Committee (GESC)
July 21, 2003
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Nature 409 15th February (2001).
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The Promise of Medical Genomics

• Identification of new genes with disease
  relevance, better diagnosis.
• Better characterization of subcategories of
  disease.
• Transcriptomics, Proteomics, Metabolomics
• Preventative Health, identification of risk
  factors.
• Pharmacogenomics--Right Drug for the Right person
  (personalized medicine).
• Gene Therapy.

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Sequence variation not seen at every position
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Were not all the same
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Genomics Education at Mayo

• Wide Audience
• Targets Staff---both Professional and Allied
  Health.
• Mayo Schools of Education (Medical School,
  Graduate school of Medicine, CME, PT,
• ?? Population (not in original charge)

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Genomics Education at Mayo

• Multifaceted
• Web-based Resources
• Newsletters
• Lectures/specific Programs
• Publications (Articles/books)
• Other

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Genomics Education Steering Committee Membership
2003
(A broad representation of Mayo staff,
volunteering their efforts with enthusiasm and
cooperation) Name Department Thomas C.
Spelsberg, Ph.D., Chair GESC Biochemistry and
Molecular Biology Stephen M. Ansell, M.D.,
Ph.D. Hematology Matthew M. Bernard,
M.D. Family Medicine John L. Black,
M.D. Psychiatry Mark E. Bolander,
M.D. Orthopedics Julie K. Brown,
R.N. Nursing Gordon W. Dewald,
Ph.D. Laboratory Medicine and Pathology Peter
L. Elkin, M.D. Area General Internal
Medicine Pamela R. Ellis Communications Jay
W. Ellison, M.D., Ph.D. Medical Genetics Jane
A. Jacobs Communications Brian H.
Kaihoi Communications Catharine
McKean Rochester Education Committee David A.
Mrazek, M.D. Psychiatry and Psychology Gloria
M. Petersen, Ph.D. Clinical Epidemiology David
B. Schowalter, M.D., Ph.D. Medical
Genetics Paul Targonski, M.D. Community
Internal Medicine Ayalew Tefferi,
M.D. Hematology Alan R. Thornhill,
Ph.D. Reproductive Endocrinology
Infertility Eric D. Wieben, Ph.D. Biochemistry
and Molecular Biology John M. Wilkinson,
M.D. Family Medicine David E. Williams,
M.D. Mayo Clinic Health Letter /
Emeritus Roger W. Harms, M.D., Chair Mayo
REC Obstetrics and Gynecology David C. Agerter,
M.D. Family Medicine Thomas M. Habermann,
M.D. Mayo Graduate School of Med/Hemat. Pamela
S. Karnes, M.D. Medical Genetics Gregory A.
Poland, M.D. General Internal
Medicine Clarence Shub, M.D. Cardiology Thomas
R. Viggiano, M.D. Mayo Medical School Educ.
Committee Richard Weinshilboum, M.D. Dir.
Mayos Genomics Research Center/Pharm. David A.
H. Whiteman, M.D. Medical Genetics
Ad Hoc
MGP
Michael J. Hovan, M.D., Scottsdale Rep. Edith
Perez, M.D., Jacksonville Rep. Paru J. David,
M.D., Scottsdale Rep.
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Subcommittees of the GESC
As of 04/30/03
Continuing Medical Education Dr. John Wilkinson,
Chair Dr. Matt Bernard Dr. David Schowalter Dr.
Alan Thornhill Publication Editorial Board Dr.
Ayalew Tefferi, Chair Dr. Steve Ansell Dr. David
Schowalter Dr. Eric Wieben Evaluation/Outcomes of
Education Success Dr. Paul Targonski, Chair Dr.
John Wilkinson Administration Ms. Cathy McKean
GESC Coordinating Dr. Tom Spelsberg, Chair Cathy
McKean, Admin Jackie House, Secretary Genomics
Liaisons Dr. Matt Bernard, Chair Dr. Steve
Ansell Dr. Brian Dawson Ms. Pamela Ellis Dr. Jay
Ellison Dr. Jennifer Hand Dr. Allan Jaffe Ms.
Cathy McKean Ms. Beth Pestka Dr. Alan
Thornhill Ms. Kim Wettleson Development
Committee Dr. Matt Bernard Dr. Eric Wieben Dr.
Mark Bolander Brian Kaihoi
Liaisons to the Genomics Research
Center Executive Committee Dr. Eric Wieben,
Chair Dr. Tom Spelsberg Communications Ms.
Pamela Ellis, Chair Dr. Matt Bernard Dr. Mark
Bolander Dr. Clarence Shub Dr. Pam Karnes Ms.
Cathy McKean Dr. David Williams GESC Executive
Subcommittee Dr. Tom Spelsberg Dr. Matt
Bernard Dr. Mark Bolander Brian Kaihoi Dr. Eric
Wieben Ms. Cathy McKean
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Liaisons Update

• 49 Department and Division liaisons
• 14 Mayo Health System liaisons
• 137 educational activities
• 60 diseases
• Monthly Newsletter
• Quarterly liaison meeting

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CME Course

• October 6-7, 2003
• Phillips Hall, Siebens
• GEP Support
• Aimed at primary healthcare providers
• Approved Category 1 CME credit

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Content 2. Innovative learning
Mon 1-5 pm
Mon 7-9 pm
Tues 1-5 pm
Genetic counseling experiential and role-play
Review test results from samples provided by
delegates
Bioinformatics resources at Mayo Clinic
Clinical vignettes to illustrate testing
algorithms QA/Audience response
The Gift Live performance followed by panel
discussion
Overview of Mayo/IBM collaboration real-time
demonstration
Genomics Education Program Website resources
Controversies in Genomics - Are you a racially
profiling doctor?
Debate Developing a population-based DNA bank
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Mayo Medical School

• May be most important target Audience
• Large component in first year cell course.
• Integrated Horizontally (reviewing/suggesting
  content to other courses).
• Integrated Vertically (3rd/4th year case
  discussions)
• Assessment strategies being developed
• Initial response well received.

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Mayo Medical School

• Core Knowledge
• Classical and atypical
• Genetic Resources
• Web based
• Genetic Providers (counselors. Consultants)
• Use of Genetic Tests
• Verify Clinical diagnosis
• Presymptomatic
• Testing Minors
• Are they the same as a blood test?
• Pharmacogenetics
• ELSI related

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IAMSE

• Medical Educators with responsibility for
  teaching fundamental sciences of medicine.
• Disciplines
• Anatomy, Behavioral Science, Biochemistry Microbi
  ology, Immunology, Pathology, Pharmacology, and
  Physiology.
• Where does Human genetics/Medical Genetics fit
  into the training programs?

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IAMSE

• Disciplines Medical Genetics
• Anatomy, Dysmorphology
• Behavioral Science, Teratology
• Biochemistry, Metabolic Genetics
• Microbiology, Ecogenetics
• Immunology, Immunogenetics
• Pathology, Pharmacogenetics
• Pharmacology, and Predictive
• Physiology.

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Goals and Accomplishmentsfor 2002/2003 (Table 1)

• Identified and trained many Department/Division
  Liaisons
• Significant development of the website as an
  educational resource
• Produced a series of articles for the Mayo
  Proceedings
• Supported the GEP in the Mayo schools
• Supported the GEP in various allied health
  groups (Nursing, Health Related Sciences, etc.)
• Organized a GEP effort in the Mayo Health
  System
• Initiated a GEP effort at Mayo Clinic
  Jacksonville and Scottsdale

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Goals and Accomplishmentsfor 2002/2003 (cont)

• Supported a Medical Grand Rounds Series on
  Medical Genomics/Proteomics
• Performed Needs Assessments Surveys among our
  staff and allied health
• Multiple presentations by GESC members and
  liaisons to various Mayo groups
• Designed a web editorial office/operation
• Obtained Tier 1 for Development funding for the
  GEP
• Wrote proposal and obtained 6 million in funds