Migration of Cells

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Migration of Cells
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Migration of PGCs

• Migration of primordial germ cells in mice
  involves Receptor Tyrosine Kinase (RTK) cKit
• Ligand for cKit is Mgf

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13.1
Homing of Primordial Germ Cells in Mice
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Neural Crest Cells
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6.8a
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Some Neural Crest Derivatives

• Pigment cells (melanocytes)
• Sensory, sympathetic and parasympathetic nervous
  system
• Endocrine tissue (adrenal medulla)
• Skeletal and connective tissue

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13.2
Migratory Pathways of Neural Crest Cells
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Neural Crest Cells Migrate Through the Anterior
(Rostral) Portion of the Somite
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06_08b
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Migration of Neural Crest

• May be guided by Eph/Ephrin system
• Eph receptors are RTKs
• Ephrins are ligands that are bound to cells

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13_03
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Differentiation of Neural Crest

• Determined mostly by their final location

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06_09a
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06_09b
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6.9