Diagnostic systems, validity, and reliability

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13er Congreso Colombiano de Psicología
Different patterns of defensive freezing response
associated with different anxiety disorders
Jesús Landeira-Fernandez
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Functions of the Nervous System
Two functions of the nervous system
Regulation of the internal environment through
homeostasis Visceral Nervous System
Interact with external environment through
behavior Somatic Nervous System
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Organization of the Nervous System
STIMULUS
BEHAVIOR
Defense Feeding Reproduction
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Organization of the Defense System
Dangerous Stimulus
Nervous System
Defensive Response
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Organization of the Defense System
Dangerous Stimulus
Innate
Cause some threat to the life to the individual
Learned
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Organization of the Defense System
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Organization of the Defense System
Danger Stimulus
Behavioral Inhibition
Freezing
Escape
Defensive Response
Fight
Behavioral Activation ACTIVITY BURST
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Organization of the Defense System
Theoretical Constructs
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Organization of the Defense System
Somatic Nervous System
Visceral Nervous System
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Organization of the Defense System
Somatic Nervous System
Visceral Nervous System
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Interaction between Pain and Fear Motivational
System
Pain motivational system activates fear
motivational system through classical conditioning
Pain Motivational System
Fear Motivational System
Contextual Fear Conditioning
Neutral Stimuli
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Interaction between Fear and Fear Motivational
System
Fear motivational system inhibits pain
motivational system through analgesia
Pain Motivational System
Fear Motivational System
Analgesia
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Interaction between Fear and Fear Motivational
System
Classical Conditioning
Analgesia
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Contextual Fear Conditioning Paradigm
First Day
000
300
320
340
400
A few minutes of habituation
Dia 1 Treinamento
A few rapid and not very intense footshocks
000
300
Second Day Testing Session
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Typical Contextual fear Conditioning Result
Freezing depends on the intensity of the shock
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Activation of the Pain Motivational System in the
Vacuum The Immediate Shock Deficit
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Activation of the fear Motivational System in the
Vacuum The Immediate Shock Deficit
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Delayed but not Immediate Shock Induces Analgesia
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Immediate Shock does not Induce Analgesia
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Opioid Analgesia
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Opioid Analgesia
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Non-Opioid Analgesia
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Fear and Pain Motivational Systems
Dangerous Stimuli
Motivational Systems
Defense Responses
Distal Innate
Fear
Freezing
Learned Innate
Classical Conditioning
Analgesia
Pain
Activity Burst
Proximal
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Fear and Pain x Anxiety and Panic
Motivational Systems
Defense Responses
Motivational Systems Dysfunctions
Fear
Anxiety
Freezing
Classical Conditioning
Analgesia
Panic Attack
Pain
Activity Burst
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Deakin-Graeff Model
Dysfunctions
Anxiety
Activates
Inhibits
Panic Attack
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Functions x Dysfunctions
Deakin-Graeff Model
Fanselow Model
Functions
Dysfunctions
Fear
Anxiety
Activates
Classical Conditioning
Inhibits
Analgesia
Panic Attack
Pain
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Animal Models to Investigate Anxiety and Panic
Attack
Contextual fear conditioning (Model of
Generalized Anxiety Disorder)
dPAG Electrical Stimulation (Model of Panic
Attack)
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Animal Model of Panic Attack
dPAG electrical stimulation
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dPAG electrical stimulation
Increasing the intensity of the dPAG electrical
stimulation there is first a freezing response
followed by vigorous running and jump reactions.
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The Periaqueductal Gray Matter
Periaqueductal Gray (PAG)
Electrode Tract
Stimulation Site in the Dorsal Portion of the
PAG
Cerebral Aqueduct
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Does Anxiety (contextual fear conditioning)
Inhibits Panic Attacks (dPAG electrical
stimulation)?
dPAG Electrical Stimulation (Model of Panic
Attack)
Contextual fear conditioning (Model of
Generalized Anxiety Disorder)
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Does Anxiety (contextual fear conditioning)
Inhibits Panic Attacks (dPAG electrical
stimulation)?
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Two Types of Freezing the context shift test
Contextual fear conditioning
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Two Types of Freezing the context shift test
Contextual fear conditioning
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Two Types of Freezing the context shift test
dPAG electrical stimulation
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Two Types of Freezing the context shift test
dPAG electrical stimulation
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Two Types of Freezing the context shift test
Contextual fear conditioning
dPAG electrical stimulation
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Two Types of Freezing
Freezing Induced by Contextual Fear Conditining
Amygdala
vPAG
Freezing
Freezing Induced by dPAG Electrical Stimulation
?
dPAG
?
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Comparison between dlPAG and vlPAG electrical
stimulation
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Comparison between dlPAG and vlPAG electrical
stimulation
Freezing after dPAG electrical stimulation
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Effect of vPAG Lesions on Conditioned and
Unconditioned Freezing
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Histology of vPAG Lesion and dPAG Electrical
Stimulation
vPAG Lesions
dPAG Electrical Stimulation
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Effect of vPAG Lesions on Conditioned and
Unconditioned Freezing
Contextual fear conditioning
dPAG electrical stimulation
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Effect of Amydgala Lesions on Conditioned and
Unconditioned Freezing
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Histology of Amygdala Lesion and dPAG Electrical
Stimulation
Amygdala Lesions
dPAG Stimulation
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Effect of Amygdala Lesions on Conditioned and
Unconditioned Freezing
Contextual fear conditioning
dPAG electrical stimulation
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Summary
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Summary
Fear Motivational System Responsibe for General
Anxiety Disorder
Pain Motivational System Responsibe for
Panic Attack
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Collaborators
Marcus Brandão USP-RP A.Pedro de Mello Cruz -
UnB Regina Nogueira - UNESA Daniel M Vianna
USP-RP Valeska Mageriek - UNIFESP
Cecília De Luca USP-RP Luciana Oliveira
USP-RP Vitor Castro PUC-Rio Bruno Galvão
PUC-Rio Bruno Larrubia PUC-Rio
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Contact
www.landeira.org landeira_at_puc-rio.br
Thanks to Fernando Cárdenas Universidad de los
Andes
Muchas Grácias !!!