Iowa Drug Information Service (IDIS)

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Iowa Drug Information Service (IDIS)
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Iowa Drug Information Service (IDIS)

• Publisher
• University of Iowa College of Pharmacy Division
  of Drug Information
• Years Covered
• 1966 to Present
• Scope
• Only includes articles about drugs in human
  therapy

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Iowa Drug Information Service (IDIS)

• Immediate access to full-text articles from 200
  English-language biomedical journals (includes
  several international journals)
• from 1988 to Present available as PDF
  document
• Prior to 1988, full-text articles are on
  microfiche

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Search Screen
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Results Screen (with Details Hidden)
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Results Screen (with Details Shown)
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Controlled Vocabulary

• Similar to MeSH terms and Limits
• Drug
• Disease
• Descriptor

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Drug

• Valid drug name is the United States Adopted Name
  (USAN).
• Valid drug number is a 7- or 8-digit modified
  American Hospital Formulary Service (AHFS)
  number.
• Therapeutic categories are arranged in hierarchal
  order.
• Examples
• 24000000- Cardiovascular agents
• 24040000 Cardiac agents
• 24040100 Cardiac glycosides
• 24040103 Digitoxin

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Disease

• Valid disease names and code numbers are from the
  International Classification of Diseases, 9th
  Revision, Clinical Modification (ICD-9-CM) (a
  commonly used system of classifying diseases).
• Example
• If you search for varicose vein in the
  Thesaurus, using the Look Up button next to the
  Disease field, or using the Disease Hierarchy,
  you will find several types of varicose veins and
  their associated codes
• VARICOSE VEIN, LW EXTREMITY 454.
• VARICOSE VEIN NEC 456.
• VARICOSE VEIN, ESOPHAGEAL 456.0
• VARICOSE VEIN, SCROTAL 456.4
• VARICOSE VEIN, VULVAL 456.6
• The periods in the codes subdivide the disease
  terms.
• The term NEC means not elsewhere classified

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Descriptor

• There are more than 150 valid descriptor terms
  (with codes) which further limit information.
  Click the Look Up button next to the Descriptor
  field to see the entire list.
• Get to know the descriptors.
• Use the Descriptor Definitions link to search for
  the definition if you dont understand what it
  means.
• Examples
• Study Randomized Adult 135
• Side Ef Musculoskeletal 77
• Adm Parent Intraarticular 114

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Descriptor Categories

• Article type (and population adult, pediatric,
  geriatric)
• Case report/series, reports, reviews, studies
  (case-controlled, cohort, randomized), government
  document, design/analysis (cross-over,
  meta-analysis, n-of-one trial, practice
  guideline, systematic review), and continuing
  education.
• Outcome
• Clinical results, economic outcomes, general
  outcomes, quality of life.

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Descriptor Categories (continued)

• Pharmaceutic
• Drug analysis, drug manufacture, drug properties,
  pharmaceutic incompatibilities, pharmaceutics.
• Therapeutic
• Route of administration, clinical
  incompatibilities (contraindication, drug
  interaction, lab interaction, dietary
  interaction), clinical issues (dosage, mechanism
  of action, modification of effect,
  pharmacodynamics), drug use, side effects/adverse
  reactions, toxicology.

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Thesaurus

• Cross references all synonyms, trade names, or
  concepts to their valid drug/disease/descriptor
  terms/codes (valid terms appear in uppercase
  followed by their code numbers).
• Note that in the Thesaurus
• (DR) drug term
• (DI) disease term
• (DE) descriptor term
• Examples
• thyroid dr locates the word thyroid in the Drug
  field
• thyroid di locates the word thyroid in the
  Disease field
• thyroid de locates the word thyroid in the
  Descriptor field

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Other Ways to Search

• Word(s) in the title and/or the abstract
• Author(s) (you can use the Look Up button next to
  this field)
• Example (enclose in quotation marks last name,
  space, first initial, space, second initial)
• Smith J P (you know the authors last, first,
  and middle if there is one initials)
• Smith J (will give you all the Smiths whose
  first name begins with J)
• Smith (will give you all the Smiths)
• Smith (will give you all the authors with
  Smith as the first 5 letters of their last names
  Smith, Smithard, Smithee, Smithells, etc.)

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Other Ways to Search (continued)

• Journal (must use the correct IDIS journal
  abbreviation use the Look Up button next to this
  field to locate the correct abbreviation)
• Volume, issue, starting page number (if known)
• Year
• Default is all years through current year.
• For 1 year, enter the same year into both the
  starting and ending year fields.
• For a range of years, enter the starting year and
  ending year.

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Other Ways to Search (continued)

• Article number (if known)
• Sequence number (if known) dont worry about
  this too much. Each article is assigned 1 unique
  article number, but sometimes it will have 2 or
  more sequence numbers if all our indexing terms
  wont fit in one record or if the article
  contains more than one primary concept.
• All fields Caution use of this field will
  result in MANY irrelevant citations (cross
  references of cross references of cross
  references, etc., in the Thesaurus are checked).
  This field is good to search for unique terms,
  abbreviations, or exact phrases that do not have
  a valid drug, disease, or descriptor term.

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Example

• Search for case reports in which rasburicase was
  used to treat acute lymphoblastic leukemia in
  children.

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Example Using the Lookup Buttons

• Drug
• Valid term/number "RASBURICASE 2000004"
• Disease
• Valid term/number "LEUKEMIA, LYMPHOID, ACUTE
  204.0"
• Descriptor
• Valid term/number "CASE REPORT PEDIATRIC 1"

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Example Using the Thesaurus

• rasburicase dr
• Locates rasburicase in the Drug field
  (RASBURICASE 2000004)
• acute lymphoblastic leukemia di
• Locates acute lymphoblastic leukemia in the
  Disease field (LEUKEMIA, LYMPHOID, ACUTE 204.0)
• case report de
• Locates case report in the Descriptor field
  there are 3 types select the one that applies to
  children (CASE REPORT PEDIATRIC 1)
• In this example, you will have to use common
  sense or the thesaurus of a dictionary to
  determine that pediatric children. Use the
  Descriptor Definitions link to find that a
  pediatric patient is a newborn to 12 years of
  age.

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Example Results

• This search yields 3 results (articles 651723,
  559551, and 505702)
• To see all the terms that were used to index the
  article, change the Output/Display Format to
  Full Results and click Adjust. This is similar
  to looking at the full citation in PubMed to get
  an idea of other terms you might want to search
  for.
• Note about Full Results You can work backwards
  if you find a relevant citation in another
  database locate the article in IDIS using the
  other fields or general terms, look at the Full
  Results of what you get to see the valid terms,
  plug them in, and redo the search to locate more
  articles on the subject.
• Click on the article number to read the article.

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IDIS Search Tips
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General Search Tips

• The key to successful searching in the IDIS
  database is being able to use and apply the Drug,
  Disease, and Descriptor fields.
• Before executing the search, make sure your
  operators make sense. If not, correct them.
  There are different defaults (and vs. or) in
  different fields.

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Truncating Words

• Use the asterisk () to truncate words. This
  will allow you to find the term if it isnt
  indexed exactly the way you think it is. For
  example, kidney ston would find kidney stone,
  kidney stones, kidney stonage, kidney stoning
  (all of these terms arent in IDIS or even real
  terms, but this is just to give you an example).
  Think about appropriate places to truncate terms.

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Words/Terms Not in Controlled Vocabulary

• Not all words/terms will have an appropriate
  controlled vocabulary term. If you try your
  absolute best and cannot find an appropriate
  term, try searching for the word or term in the
  Title, Abstract, or All Fields field.

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Sources of Help Within IDIS

• Help link
• Links on the left side of the screen
• Information button (i) next to each field

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Thesaurus

• The Thesaurus is the official dictionary of
  controlled vocabulary terms.
• Dont forget to add DR, DI, or DE, depending on
  what you are looking for so that you wont have
  to scroll through irrelevant terms.

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Exploding Drug Classes

• Explode drug classes by locating the class in the
  Thesaurus, and truncating the drug code at the
  appropriate place.
• For example, if you search 24040100 (cardiac
  glycosides a class of drugs), your search will
  only retrieve articles that talk about that class
  in general. It will not locate articles about
  the individual drugs in the class. If you wanted
  information about all cardiac glycosides, you
  should search 240401. This will pick up 24040101
  (deslanoside), 24040102 (digitalis), 24040103
  (digoxin), etc.

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Population Tags

• IDIS uses population tags in the Disease field
• Neonate, pediatric, puberty and adolescence, and
  geriatric are all population tags that can be
  used in the Disease field (search the Thesaurus
  for them).
• If you are looking for any type of article
  related to one of these age groups, use the
  appropriate population tag in the Disease field
  (instead of searching for the age group using an
  article type in the Descriptor field).

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Article Classifications Without Descriptors

• Search Author field for
• Editorial - editorial
• Letter to ed letter to the editor
• Search Disease field for
• Corrigendum erratum, addendum, retraction
  (type will be indicated in Title field)

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Specific Types of QuestionsSide/Effect Adverse
Reaction Caused by a Drug

• Locate articles about a side effect/adverse
  reaction that a drug causes
• Drug
• Enter the drug that is causing the side
  effect/adverse reaction.
• Disease
• In general, you wont need a disease term because
  the drug will likely cause the side
  effect/adverse reaction in all diseases, so
  disease isnt important in these cases (unless
  the question specifies a specific disease).
• Descriptor
• Use the appropriate side effect/adverse effect
  descriptor. Searching the Thesaurus for drug
  induced and the side effect/adverse reaction
  that you are looking for will usually provide the
  correct descriptor.

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Specific Types of QuestionsDrug Used to Treat
Side Effect/Adverse Reaction

• Locate articles about a drug that is used to
  treat a side effect/adverse reaction of a drug
• Drug
• Enter the drug that is being used to treat the
  side effect, NOT the drug that caused it .
• Disease
• Enter the term TX/AE-Drug/Chemical E999. plus
  the disease term/code for the disease that the
  drug caused.
• Descriptor
• Generally will not use a side effect/adverse
  reaction descriptor unless it has to do with the
  drug that is in the Drug field. Other types of
  descriptors may apply if the question calls for
  it.

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Specific Types of QuestionsDrug Interactions

• Locate articles about two or more drugs that
  interact
• Drug
• Enter all drugs that interact (use AND operator).
• Disease
• Generally wont use
• Descriptor
• Drug interaction 50 and Drug combination 16
• Alternatively, you can enter
• 50 and 16

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Specific Types of QuestionsDrug Used to Prevent
a Disease

• Find articles about a drug(s) that are used to
  prevent a disease
• Drug
• Enter the drug(s) that is/are being use to
  prevent the disease.
• Disease
• Enter the term Prophylaxis NEC V07. plus the
  disease term/code that the drug is preventing.
• Descriptor
• As indicated.

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Specific Types of QuestionsSuicide/Overdose/Pois
oning

• Find information about a drug that someone has
  overdosed or been overdosed on, has tried to
  commit suicide with, has been poisoned with, or
  is showing signs of toxicity from
• Drug
• Enter the drug(s) of interest.
• Disease
• Enter the term/code Suicide/Overdose/Poisoning
  E950.
• Descriptor
• As indicated.