Technical Working Group

1
Technical Working Group

• Leader Kathryn C. Zoon, Ph.D.
• Deputy Director Planning and Development
• Principal Investigator
• Division of Intramural Research, National
  Institute of Allergy and Infectious Diseases
• National Institutes of Health

2
Goals

• Identify areas of priority for harmonization/conve
  rgence and areas where it is not possible
• Propose next steps for accelerating existing
  efforts
• Propose new initiatives in areas where none
  currently exist

3
Emphasis on

• Reference materials and standard controls
• Reporting standards
• Probabilistic outcomes decision making

4
Areas of Standardization

• Technical
• Sample preparation -Probes
• Instrumentation -Hybridization
• Array fabrication -Scanning
• Different platforms
• Labeling
• Computational
• Image quantification -Data normalization
• Data management -Statistical methods
• Data processing -Evaluation of data quality
• Interpretive
• Output from computational analysis

5
Areas of Standarization

• Gene Expression Microarrays
• Other Genomic and Genetic Tests