Nessun titolo diapositiva

1
Garbisa 2001
Is EGCG active on thrombin (Th) ?
( thrombin gt fibrinogen gt fibrin gt clot )
Kang et al., Throm.Res. 96, 229-237, 1999
inhibits platelet aggregation
prevents pulmonary thrombosis
without changing coagulation parameters (proTh
and Th-time)
2.2 mM
2
Garbisa 2001
Is EGCG directly active on thrombin (Th) ?
?
(Kang 99)
LE
MMP-2
Th
cath.G
uPA (Jankun 97)
MMP-12
(Demeule 00)
other serine-proteinases
metallo-proteinases
Differential enzyme inhibition by EGCG
EGCG useful in clinical application
(inflammation), preserving cathepsin G- or
uPA-mediated reactions
(Sartor L., Pezzato E., Garbisa S., submitted to
J.Leuk.Biol. 2001)