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Mechanism of capping viral capping enzyme

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Can produce up to 38016 different protein isoforms. Pre-mRNA editing by Adenosine deamination ... Drosophila. genes. Pumilio domain (Wang et al, Cell, 2002) dsRBD-RNA ... – PowerPoint PPT presentation

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Title: Mechanism of capping viral capping enzyme


1
Mechanism of capping (viral capping
enzyme) PP-RNA GMP G-PPP-RNA
Hakansson et al et Wigley, Cell 1997
2
CBP20-m7GpppG contacts
3
Alternative-splicing of the DSCAM gene
Can produce up to 38016 different protein isoforms
From Black D.L. Cell (2000), v103 p367
4
Pre-mRNA editing by Adenosine deamination
Human genes
Drosophila genes
From Reenan Trends in Genetics (2001), v17 p53
5
Pumilio domain
(Wang et al, Cell, 2002)
6
(No Transcript)
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(No Transcript)
8
dsRBD-RNA
Ryter and Schultz, Embo J, 1998
9
Zinc finger-RNA
(Lu et al, Nature , 2003)
10
Zinc finger4-RNA
Zinc finger4-DNA
(Lu et al, Nature , 2003)
(Nolte et al, PNAS , 1998)
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