Ziconotide Prialt

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ZiconotidePrialt

• Therapeutic targets for pain
• intervention

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Ziconotide
Ziconotide, has been recently approved by FDA as
an analgesic for management of severe and chronic
pains.
Intrathecal administration
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Ziconotide

• ?-Conotoxin, MVIIA or SNX-111
• 25-amino acid peptide ( from Conus magnus )
• Six cysteine residues linked by 3 disulfide
  bonds

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Ziconotide

• Mechanism
• Selectively and reversibly blocks the N-type VCC
  on the primary nociceptor nerve in spinal cord
• (animal model)

Inhibits the releasing of
-neuropeptides -substance
P -Calcitonin gene-related
peptide (CGRP)
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L-type Ca2 channel antagonists
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N-type Voltage-gate Ca2 channel
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ziconotide
Binding of Ziconotide and N-type VCC