Insulin Resistance and PCOS

1
Insulin Resistance and PCOS
2
Conclusions

• Increasing evidence that PCOS is associated with
  insulin resistance
• Data seems to suggest differences between IR
  associated with obesity and IR associated with
  PCOS
• Data also notes peripheral IR and maintenance of
  ovarian insulin sensitivity

3
Conclusions

• Obese and lean PCOS phenotypes
• Ovarian androgen dysregulation may be a primary
  pathogenetic mechanism
• Serine phosphorylation may link post- receptor
  insulin resistance and selective uncoupling of
  ovarian thecal androgen biosynthesis

4
Conclusions

• Implications for PCOS-insulin resistance
  cardiovascular risk, conversion to glucose
  intolerance
• Associated with oligomenorrhea
• Metabolic syndrome profile
• Obesity is augmentative