South Dakota Signal Transduction Center

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South Dakota Signal Transduction Center

• M. Benjamin Perryman, PhD
• A. Martin Gerdes, PhD

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Center Participants

• Primary
• A. Martin Gerdes, PhD
• M. Benjamin Perryman, PhD (Co-PI)
• Timothy D. OConnell, PhD
• Kristi A. Egland, PhD
• Secondary
• Stephen Armstrong, PhD
• XJ Wang, MD, PhD
• Qiangrong Liang, PhD
• Faqian Li, MD, PhD
• Maria Bell, MD
• John Brannian, PhD
• Keith Hansen, MD

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Mission of 2010 Center

• To organize a critical mass of researchers,
  develop research infrastructure, and produce
  preliminary data necessary to compete
  successfully for federal and private grant
  support.

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2010 Research Focus Signal Transduction

• Signal transduction pathways regulate cellular
  functions.
• Genomics research revealed that many disease
  processes are interrelated.
• Diseases are linked by signal transduction
  pathways they have in common.
• Understanding these pathways illuminates
  potential for prevention and cures.

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Signal Transduction A cellular communication
process

• Messages from external environment are
  transmitted to internal environment.
• Messages provoke cellular responses.

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Messages Stimuli

• Physical Messages
• compression
• stretch
• temperature

• Chemical Messages
• hormones
• acids and bases
• oxygen

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Cellular Responses

• Physical Responses
• dividing
• changing shape
• migrating or docking

• Chemical Responses
• producing biomolecules
• transmitting information
• specializing function
• dying

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Signal Transduction Center 2010 Projects

• Gerdes
• Signaling associated with mechanisms of
  congestive heart failure
• OConnell Adrenergic receptor signaling in
  cardiac muscle cells
• Perryman Molecular pathology of hypoplastic left
  heart syndrome
• Egland Defining the role of a novel receptor in
  breast cancers

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Significance

• Signal transduction mechanisms are a foundation
  of modern biology and medicine
• Research projects focus on cardiovascular disease
  and cancer, the most common causes of sickness
  and death in Western societies

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Cardiovascular Disease and Cancer the most
common causes of sickness and death

• According to CDC/NCHS, the probability of dying
  from
• Cardiovascular disease 47
• Cancer 22
• Eliminating these diseases would increase life
  expectancy by 10 years
• 7 years for cardiovascular
• 3 for cancer
• (based on 2000 population data, average 77.3
  years)

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Cardiovascular Disease

• 1 killer in US for more than a century
• 38 of all deaths in 2002
• 2,600 Americans each day
• One every 34 seconds
• 1 killer in SD
• 2,648 people in 2001
• Caused 38.1 of deaths (1 of every 2.6)
• 70.1 million people afflicted in 2002
• 43.1 million UNDER age 65
• 2 cause of death under age 15

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Cancer

• 2 killer in 2005
• US - 570,280 deaths
• South Dakota 1,620 deaths
• 1.4 million new cases nationwide
• 3,900 of them in SD
• Probability of developing invasive cancer
• Men 46 chance (1 in 2)
• Women 38 chance (1 in 3)
• (Reference interval 1999-2001)

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Benefits/Outcomes of 2010 Center

• Signal Transduction Center is
• a basic science entity
• Products Benefits
• Knowledge (societal benefit)
• Money (economic benefit)

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Halfway Technology A Case Study
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• Halfway technology represents the kinds of
  things that must be done after the fact, in
  efforts to compensate for the incapacitating
  effects of certain diseases whose course one is
  unable to do very much about. By its nature, it
  is at the same time highly sophisticated and
  profoundly primitive

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It is characteristic that it costs an enormous
amount of money and requires continuing expansion
of hospital facilities. It is when physicians
are bogged down by their incomplete technologies,
by the innumerable things they are obliged to do
in medicine, when they lack a clear understanding
of disease

• mechanisms, that the deficiencies of the
  health-care system are most conspicuous

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• The only thing that can move medicine away from
  this level of technology is new information, and
  the only imaginable source of this information is
  research. The real high technology of medicine
  comes as the result of a genuine understanding of
  disease mechanisms and when it becomes

available, it is relatively inexpensive,
relatively simple, and relatively easy to
deliver. Lewis Thomas (From Lives of a
Cell)
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Contrast

• Halfway Technology
• Medicare/Medicaid 177.6 billion FY2005
• Private/public health care spending FY2000
• 1.1 trillion spent in US
• 3.0 billion in South Dakota
• Real Technology
• Research investment FY2005
• NIH 31.1 billion
• NSF 4.6 billion
• South Dakota 2010 Initiative Research Centers
  Program

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Outcomes of Knowledge

• Used and commercialized by applied science
  entities (biotechnology and pharmaceutical
  companies) to ultimately increase quality and
  quantity of life and generate wealth
• Allows Center to successfully compete for federal
  and private grant money

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Immediate Economic Benefits of 2010 Center

• Creates professional jobs
• Purchases goods and services
• Provides training/educational opportunities

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Immediate Economic BenefitMoney into South Dakota

• Measures
• Number grants funded
• Success rate of grant proposal submissions
• Dollars won (revenue)

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Revenue FY 2006
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2010 Center Revenue

• FY 2003 3.1 million
• FY 2004 4.0 million
• FY 2005 4.7 million
• FY 2006 6.1 million (projected)
• FY 2007 10.2 million (projected)

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2010 Center Revenue Sources
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Immediate Economic BenefitJobs for South
Dakotans
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2010 Center Provides Jobs
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Wages and Fringe Benefits
Million
FY 2005
FY 2006 projected
FY 2007 projected
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Immediate Economic Benefit Education/Training
Opportunities

• Enables Sioux Falls research community to
  exchange graduate level coursework with other
  locations
• Exposes students to research techniques,
  approaches, and culture

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Long-Term Economic Benefits

• 2010 Research
• Improves state research infrastructure providing
  opportunities for future technology and applied
  science industries

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2010 Center Leverages State Money
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2010 Center is Sustainable
2.5x greater
FY 2005
FY 2009
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South Dakota Stories

• Brent Anderson, BS
• Casey Wright, PhD

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South Dakota Story Brent Anderson

• Born with a serious heart defect
• Eagle Scout
• Harrisburg HS 1990
• Heart transplant at 19
• BS 2000 from USD
• Employed at Cardiovascular Research Institute
  from 2000-2005
• Advanced from trainee to Lab Manager
• Died at 34, awaiting second transplant
• Co-author of five publications, others
• in press

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South Dakota Story Casey Wright

• Born in Sioux Falls
• 1994 Brandon HS
• 1998 BS from SDSU
• 2000 MS from SDSU
• 2005 PhD from Colorado State University
• Able to return to SD for post-doctoral fellowship
  in OConnell Lab

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2010 Center Revenue in Perspective

• Center revenue FY2005 0.17 (about 1/600)
• of Total State Expenditures FY2003
• 2010 revenue roughly equivalent to cost of public
  assistance

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2010 Center Revenue in Perspective

• 2010 Initiative Goal Increase SD gross state
  product by 38 or 10 billion
• 15 or 4 billion from growth of existing
  enterprises
• 2010 Center Contribution
• Since 2003, Center increased revenue by 57 (1.8
  million)
• By 2010, over 200 increase (6.7 million)
  projected

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Opportunities for Collaboration

• Share core services?
• Share high-cost equipment?
• Share graduate level coursework?