5,10methenyl

1
Courtesy of J Ordovas, used by permission
Pi PPi
ATP
THF
methyl acceptor
MS
5-methyl- THF
5,10-methylene- THF
methylated product
MTHFR
MTHFD
CBS
5,10-methenyl- THF
cystathionine
cystathionine
Figure 1 A simplified scheme of folate-dependent
homocysteine metabolism. CBS, cystathionine
beta-synthase. MS, methionine synthase MTHFR,
5,10-methylenetetrahydrofolate reductase MTHFD,
5,10-methylenetetrahydrofolate dehydrogenase
SHMT, serine hydroxymethyl transferase
2
Courtesy of J Ordovas, used by permission
P0.006
P0.01
Figure 2 Odds ratios and 95 confidence
intervals for the prevalence of the TT genotype
at the C667T-MTHFR polymorphism in early onset
(28) versus later CAD onset patients (13
p0.006) and between early onset patients and
control subjects (14 P0.01)