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frizzled
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LEF/ TCF. Target Genes. E-cadherin -catenin. Activated Cells: frizzled. conductin/axin ... slimb. P. APC. LEF/ TCF. Target Genes. E-cadherin -catenin. Loss ... – PowerPoint PPT presentation
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Title: frizzled
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Quiescent Cells
frizzled
E-cadherin
? -catenin
P
slimb
?-catenin
GSK3?
? -catenin
conductin/axin
APC
LEF/ TCF
Target Genes
4
wnt
Activated Cells
frizzled
dsh
E-cadherin
? -catenin
P
slimb
?-catenin
GSK3?
? -catenin
conductin/axin
APC
LEF/ TCF
Target Genes
5
Loss of APC
frizzled
E-cadherin
? -catenin
P
slimb
?-catenin
GSK3?
? -catenin
conductin/axin
APC
LEF/ TCF
Target Genes
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(No Transcript)
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