frizzled

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Quiescent Cells
frizzled
E-cadherin
? -catenin
P
slimb
?-catenin
GSK3?
? -catenin
conductin/axin
APC
LEF/ TCF
Target Genes
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wnt
Activated Cells
frizzled
dsh
E-cadherin
? -catenin
P
slimb
?-catenin
GSK3?
? -catenin
conductin/axin
APC
LEF/ TCF
Target Genes
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Loss of APC
frizzled
E-cadherin
? -catenin
P
slimb
?-catenin
GSK3?
? -catenin
conductin/axin
APC
LEF/ TCF
Target Genes
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