Phantom limb pain

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Phantom limb pain
What is happening in injury site?
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(No Transcript)
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Imaging
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Recording
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Immunolabeling
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• Axon cut
• Nearby cells produce NT factors
• Sprouts grow
• Axons excited by unrelated signal

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• Tissue injury
• Inflammatory factors
• secretion demyelinisation
• Signal to produce more mRNA
• Increase in number of channels
• Raised excitability

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A huge number of factors observed, but which is
primary?
Or combination?
Or all of them...