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Title: Stress


1
Stress Cancer Projects Spring/Summer2004
Volume 1 Number 2 I asked for strength was
given difficulties to make me strong. I asked
for wisdom was given problems to solve. I
asked for courage was given danger to overcome.
I asked for love was given troubled people to
help. I asked for favors was given
opportunities. I received nothing I wantedI
received everything I needed. -Author Unknown,
Poem read by Stefanie Speilman at 2003
Annual Community Gathering
  • Overview of Community Gathering 2003
  • Thank you to all of you who attended our 4th
    Annual Reception. The theme was Celebrate the
    Champion Within. The guest speakers included
    breast cancer survivor advocate Stefanie
    Spielman, Dr. Charles Emery, who spoke about the
    benefits of regular exercise, Principal
    Investigator Dr. Barbara Andersen, who is
    featured in our Spotlight section found on page
    2.
  • The reception was a great success again this
    year, the success of the project itself could
    not be completed without all of you. Thank you!
  • Upcoming Events
  • We are only 4 months away from our 5th
    Anniversary Annual Community Gathering! Mark your
    calendars for 10/4/04. The theme for this years
    event will be Escape for an Evening will
    feature a fun, tropical atmosphere. We will also
    provide you with a copy of one of our most recent
    publications accepted June 2004.
  • We had such a great turnout last year, hope to
    see even more of you this year. You are always
    welcome to bring a guest, so even if you have
    never attended before, please come see what you
    have been missing. We promise this will be one of
    our best gatherings yet!
  • Just For You!
  • The Comprehensive Cancer Center chronicle,
    Frontiers, sent with this newsletter comes to you
    compliments of the Stress and Immunity Cancer
    Project. It contains several articles that may be
    of interest to you, including those featuring
    SIBCPs principal investigator Dr. Andersen,
    concerning psychological studies, a
    Co-investigator for the project Dr. Carson, which
    concerns immunotherapies. These articles may be
    found on pages 24 20, respectively.
  • Project News
  • Research Assistant Lyne Charbonneau, who was
    responsible for much of the behind the scenes
    work for the project has recently moved with her
    husband, cancer researcher Dr. Martin Guimond,
    who has accepted a position at the NIH in
    Washington D.C. Dr. Deanna Golden-Kreutz, after
    over 11 years of devoted service to the project,
    will be working in the hospital with clinical
    trials but will remain available to the project.
    We thank them both for their dedication and hard
    work.
  • Also, we have had two new Research Assistant
    additions to the Project Staff. Please help us in
    welcoming Carolyn Hagopian, who will be seeing
    some of you at your next assessment, Theresa
    Paulin who will be assisting in data management.

1885 Neil Avenue, Columbus, OH 43210
Phone (614) 292-8429 Fax (614) 292-7728
2
Spotlight Dr. Barbara Andersen
Principal Investigator of SICP
Professor of Psychology, Obstetrics,
Gynecology Receives Distinguished Lecturer
Award
  • Dr. Barbara Andersen
  • The Ohio State University Distinguished Lecture
    Series annually recognizes two senior faculty
    members for their outstanding academic
    achievement, particularly, but not exclusively,
    in research, scholarship, or creative activity.
    Each recipient presents a scholarly lecture, open
    to the university community and to the public,
    followed by a reception.
  • Barbara Andersen is an individual who is
    recognized internationally for her outstanding
    and pioneering contributions to the field of
    psychosocial cancer research, wrote Francis J.
    Keefe, professor of psychiatry and behavioral
    sciences at Duke University Medical Center. In
    the early 1980s, Barbara was one of the first
    psychologists to study how women adjust to
    gynecologic cancer. Overall, her programmatic
    research is outstanding and serves as the gold
    standard against which others can be compared,
    Keefe wrote.
  • Susan Folkman, professor of medicine and
    director of the Osher Center for Integrative
    Medicine at the University of California at San
    Francisco, wrote Medical educators are just
    beginning to respond to the public demand for
    more humane medical care. Work such as Professor
    Andersens is invaluable in these efforts.
    Medicine is waking up to the fact that
    psychological well-being is not a trivial outcome
    of cancer treatments. Professor Andersens work
    will help lead the way to interventions of this
    sort for diverse cancer populations.

Andersen received her bachelors, masters and
doctoral degrees in clinical psychology from the
University of Illinois and joined Ohio States
faculty in 1989. Her publications include three
books and more than 125 empirical and scholarly
articles. In 2000, she received Ohio States
Distinguished Scholar Award. This is a
wonderful and very unique honor, Andersen said.
It is also a tribute to the patients, graduate
students, staff and my oncology and psychology
colleagues who have breathed life into our cancer
research. The story of living with cancer is an
important one. To view the lecture online,
please visit http//www.osu.edu/lecture/archive
/index.html Please Remember! ? Also, if you
are coming to OSU Hospital for your next
assessment please note the move of the CRC from
Rhoades Hall to Dodd-Davis Hall. You should have
received a map in the mail, however, if you have
any questions or are in need of a new map, please
dont hesitate to call! ? To assist with an
easier blood draw, drink plenty of water avoid
caffeine fruit juices 12-24 hours before your
next assessment! ?You can keep up to date on
all of the latest SICP information and
publications by visiting our website at
www.meaningoflifestudy.org
1885 Neil Avenue, Columbus, OH 43210
Phone (614) 292-8429 Fax (614) 292-7728
3
Recent Publications
  • This study represents the first instance of
    long term immune benefits in response to taxane
    administration, a finding that runs counter to
    currently held beliefs about the effects of
    chemotherapy on immune function.  This is just
    another important example of how your
    participation in this project has contributed to
    basic research in cancer, research that provides
    important information about the benefits of a new
    cancer treatment, such as taxol.  BRAVO to you
    all!
  • Andersen B. L., Carson III, W. E. Crespin, T.
    R., Shapiro C. L., Thornton, L. M. Cellular
    Immunity in Breast Cancer Patients Completing
    Taxane Treatment Clinical Cancer Research Journal
    Volume 10, May 15th edition.
  • Summary of The Gynecologic Oncology Consult
    Symptom Presentation and Concurrent Symptoms of
    Depression and Anxiety
  • This article examines the relationship between
    gynecologic symptoms and socio-demographic
    variables and symptoms of depression and anxiety
    among women referred to gynecologic oncologists
    for evaluation, all of whom were eventually
    diagnosed with either gynecologic cancer or
    benign gynecologic disease. 
  • Results indicated that women in both disease
    groups experienced significant levels of
    depression and anxiety during their initial visit
    to the oncologist.  Data analyses revealed that
    women who were younger, without a spouse/partner,
    and who had more gynecologic symptoms, such as
    vaginal bleeding, reported higher levels of
    distress.  For those women with partners,
    lengthier relationships appeared to offer
    protection from this distress during oncology
    consultation.
  • Andersen, B., Carpenter, K., Fowler, J.,
    Golden-Kreutz, D., and Gupta, P. The
    Gynecologic Oncology Consult Symptom
    Presentation and Concurrent Symptoms of
    Depression and Anxiety

Summary of Cellular Immunity in Breast Cancer
Patients Completing Taxane Treatment
Chemotherapy is believed to suppress immune
function .  However, most research to date has
not been conducted with actual patients but
rather by adding chemotherapy drugs to blood
samples taken from small numbers of individuals,
often times non cancer patients.  In addition,
immune function in these studies is only examined
over a short span of time (days).  The data from
the Stress and Immunity Breast Cancer Project, on
the other hand, provided Drs. Carson and Shapiro
the opportunity to conduct a study which could
make an important, new contribution.  For this
study we combined patients from both study
arms--women who participated in the intervention
groups as well as women who did not.  We then
divided everyone into one of two groups--women
who received  any taxane-based chemotherapy
(taxol) and women who did not.  We measured
immune function two ways (1) natural killer cell
cytotoxicity, the ability of natural killer (NK)
cells to lyse (kill) target cells, and (2) T-cell
blastogenesis, the ability of T-cells to
proliferate (reproduce themselves) in response to
PHA (phytohemagglutinin a plant chemical
commonly used to stimulate T-cell reproduction).
  Both NK and T cells are believed to be
important in the body's natural defense against
cancer.  We also measured immune function at two
time-points when you began the study (right
after your surgery) and 12-months later.  These
time points also correspond to the time before
beginning chemotherapy and a time when
chemotherapy had ended. Our statistical analyses
showed that the women who received taxane-based
chemotherapy (taxol) had higher immunity at 12
months than women who did not receive taxol. 
There was higher PHA-induced blastogenesis and
higher NK cell cytotoxicity (i.e., women's T and
NK cells were more effective at dividing and
multiplying and more effective at killing 'bad'
cells).
1885 Neil Avenue, Columbus, OH 43210
Phone (614) 292-8429 Fax (614) 292-7728
4
Odds Ends
  • What does it all mean?
  • Here are some definitions to help make
  • it all come together!
  • Taxanes- A group of chemicals found in various
    types of yew trees. They have shown to be
    effective in combating some types of cancer,
    especially when combined with other types of
    chemotherapy.
  • Lymphocyte- A white blood cell which is present
    in the blood, lymph and lymphoid tissue.
  • Blasto-genesis- The transformation of
    lymphocytes into larger cells capable of
    undergoing mitosis.
  • Cyto-toxic- Something that is toxic to cells, as
    in cancer cells.
  • NK (natural killer) cell- Immune cells that can
    recognize and kill both non-self (e.g. bacteria)
    and self (e.g. tumor) cells. They contain
    granules filled with potent chemicals, and kill
    on contact.
  • T-cell- A specific type of white blood cell. All
    white blood cells are born inside of your bones,
    in the bone marrow, and at this point, they're
    called "stem cells." Some mature in the bone
    marrow and become B-cells, while other stem cells
    migrate from the bone marrow to an organ called
    the thymus-a chestnut sized gland at the base of
    the throat-where they mature into T-cells. Both
    B-cells and T-cells are crucial for the immune
    system to help fight infections and disease.
  • Heres to your health!
  • Enjoy Summers bounty of fresh healthy fruits
    in this tasty desert from the American Cancer
    Societys Healthy Eating Cookbook!
  • Summer Strawberry Shortcake
  • 2 pints strawberries, washed, hulled,
    halved
  • ½ c regular or sugar-free strawberry
    preserves
  • ¼ c honey
  • 1 TBS lemon juice
  • 3 c low-fat or fat-free whipped topping
  • 1 loaf fat-free pound cake, sliced into 12
    pieces-(toasted if desired)
  • Set aside a few strawberries to use as a
    garnish. Combine strawberries, preserves, honey,
    lemon juice in a medium bowl. Place 1 slice of
    pound cake onto dessert plate. Spoon some of the
    strawberry mixture over cake spread 2 TBS.
    whipped topping over mixture.
  • Top with another slice of pound cake, spoon more
    of the strawberry mixture over cake top with a
    dollop of whipped cream garnish with reserved
    strawberries. Serve immediately, serves 6.

1885 Neil Avenue, Columbus, OH 43210
Phone (614) 292-8429 Fax (614) 292-7728
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