Tobacco Control Research Priorities at the National Cancer Institute

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Tobacco Control Research Priorities at the
National Cancer Institute

• STEP UP to Tobacco Control Advancing the Role of
  Public Health and Public Health Professionals
• April 15, 2004
• Mark Parascandola
• Epidemiologist/Program Director
• Tobacco Control Research Branch
• National Cancer Institute

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Tobacco Control Research Branch

• Established in October 1998 to provide a focal
  point for tobacco control research within the
  Division of Cancer Control and Population
  Sciences.
• One of five branches under the Behavioral
  Research Program.
• Tobacco Control
• Applied Cancer Screening
• Basic Bio-behavioral
• Health Communications and Informatics
• Health Promotion

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Tobacco Control Research Branch

• Our Vision A world free of tobacco use and
  related cancer and suffering.
• Our Mission to lead and collaborate on
  research, and to disseminate evidence-based
  findings to prevent, treat, and control tobacco
  use.
• Our Research Spans
• - Discovery generate new information about the
  causes of tobacco use, addiction, and
  tobacco-related cancers.
• - Development create and evaluate tools and
  interventions to understand and treat tobacco use
  and addiction.
• - Delivery apply, promote, and disseminate
  evidence-based interventions in clinical and
  public health practice, and policy development.

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The Critical Importance of Translation

• In the U.S.both health providers and
  members of the public, are not applying what we
  know. Indeed, medical researchers and public and
  political leaders are increasingly talking about
  the lack of success we have had in translating
  research findings into medical practice and
  personal behavior. Regardless of the reasons
  cited structural, economic, or motivational
  the result is the same we are not reaping the
  full public health benefits of our investment in
  research. (emphasis added)
• Lenfant, C. New England Journal of Medicine,
  August, 2003.

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Research Priorities NCI Bypass Budget 2005

• Tobacco use identified as an Area of Public
  Health Emphasis.
• 75 million in FY 2005 to study tobacco use and
  tobacco-related cancers

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Submitting a Successful Grant ApplicationProcess
Overview
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Applications Submitted to NIH

• 46,000 grant applications submitted each year
• 25-30 are funded
• 3,200 review meetings
• 80 National Advisory Committees
• 200 million pieces of paper
• Electronic submission updates

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Submitting a Successful Grant Application
Process

• NIH Guide to Grants and Contracts
• This is the official document for announcing the
  availability of NIH funds for biomedical and
  behavioral research and research training and
  disseminating policy and administrative
  information.
• http//grants1.nih.gov/grants/guide/index.html
  

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Submitting a Successful Grant Application
Process

• Review the NIH Guide to Grants and Contracts
• Program Announcement (PA) statement of ongoing
  research interest by Institute/Center
• Request for Applications (RFA) special research
  initiative funds set aside and special review
• Request for Proposals (RFP) call for contract
  proposals

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Submitting a Successful Grant Application
Process

• Survey active research
• CRISP
• Cancer Research Portfolio
• DCCPS Current Research

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Funding Mechanisms

• R01 Research Grant Project - Traditional
  investigator-initiated grant. A specified
  research project to be performed by a named
  investigator in an area of interest.
• R03 Small Research Grant - for new investigators
  to conduct preliminary research.
• Usually
• R21 Exploratory/Developmental Grant -
  pre-intervention research testing novel or
  creative approaches.
• 100K/yr for 2 yrs
• R25 Cancer Education Grant - Includes short
  courses, seminars, and hands-on experiences for
  continuing education of professionals,
  researchers, and community members.
• R13 Conference Grant - supports national or
  international meetings, conferences, and
  workshops.

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Current TCRB Funding Initiatives

• Transdisciplinary Tobacco Use Research Centers
• Tobacco Research Initiative for State and
  Community Interventions (TRISCI)
• Analysis of Tobacco Industry Documents
• International Tobacco Research and Capacity
  Building
• Prevention and Cessation of Tobacco Use by
  Children and Youth in the U.S.
• Many grants funded through unsolicited pool

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DCCPS Tobacco Research Grants Funded Through
RFA/PA in FY2001
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TTURCs

• Aims Stimulate integrated research that will
  advance our understanding of tobacco use and
  nicotine addiction, and to help translate the
  results and implications of the work for policy
  makers, practitioners, and the public.
• 7 centers funded. New round of applications has
  been accepted and will be reviewed this summer.
• 70M collaborative effort between NCI and NIDA.
  14M from Robert Wood Johnson for tobacco-related
  policy research and communications. NIAAA
  collaborating in current round.

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TTURC Research Centers

• Brown University
• Georgetown University
• University of California, Irvine
• University of Minnesota
• University of Southern California
• University of Wisconsin
• Yale University
• http//www.tturcpartners.com/

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TTURCs

• Tobacco Use Prevention Across Cultures
• PI- C. Anderson Johnson, University of
  Southern California
• examines cultural factors associated with youth
  prevention, smoking progression, response to
  media advertising, and smoking exposure and
  childhood respiratory illness and symptoms.
• Smoking Topography and DNA Adducts
• PI-Peter G. Shields, Georgetown-UPenn
• examines the associations of genes with smoking
  behavior and exposure and resultant harm from
  tobacco. This research explores racial
  differences in smoking topography and the harmful
  effects of tobacco smoke exposure.

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Tobacco Research Initiative for State and
Community Interventions (TRISCI)

• Aims Designed to support research on innovative
  tobacco prevention at the community, state, or
  multi-state level, and emphasize collaboration
  between researchers and state programs.
• 19 grants awarded.
• Total support ?19-20 million per year.

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Collaborations and Networks with a Goal of
Translating Research to Practice

• Building on our long history of, and commitment
  to, major comprehensive tobacco control
  initiatives at NCI COMMIT, ASSIST,
  investigator-initiated research
• Collaborating with CDC/OSH, especially the
  National Tobacco Control Program
• Building networks of people doing state
  community tobacco control research
• Focusing on translating research to
  practicemajor priority
• Promoting the concept practice of
  Community-Based Participatory Researchreal
  Partnerships!

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Fogarty International Research

• Aims Reduce the burden of tobacco in low- and
  middle-income nations by conducting
  observational, intervention, and policy research
  of local relevance.
• Build capacity in epidemiological and behavioral
  research, prevention, treatment, communications,
  health services, and policy research.
• Build greater understanding of the many
  socio-cultural issues related to tobacco.

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Fogarty International Research

• 14 research and training grants funded.
• Total support ?20.5M over 5 years.
• Partners include NCI, NHLBI, NICHD, NIDA, NINR,
  CDC, the Canadian Institutes of Health Research,
  and the World Health Organizations Tobacco Free
  Initiative.
• Countries South Africa, Cambodia, China, Egypt,
  India, Indonesia, Senegal, Tanzania, Dominican
  Republic, Argentina, Russia, Brazil, Mexico,
  Eastern Mediterranean.

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Youth Prevention and Cessation

• Aims Designed to fund innovative research which
  has clear implications for the immediate and
  significant reduction of tobacco use by youth in
  the United States.
• 29 grants, 20 of which are funded through NCI
  (others by NIDA - 5, NICHD 2, NIDCR 1,
  NINR 1).

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Tobacco Industry Documents

• Aims Designed to stimulate research on a wide
  variety of scientific, technical, marketing, and
  tactical undertakings by the tobacco industry,
  which were documented in previously confidential
  industry records.
• 17 grants funded.
• Approximately 6-7 million per year.

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Other Initiatives

• National Cancer Institutes Smoking Quitline
• 1-877-44U-Quit
• www.smokefree.gov
• Monograph 15, Those Who Continue to Smoke Is
  Achieving Abstinence Harder and Do We Need to
  Change Our Interventions?
• Tobacco Intervention Research Clinic
• NCI Tobacco Control Investigators Meeting
  Synthesizing Research for the Publics Health,
  June 2-4, San Diego, CA

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Current Funding Opportunities

• Social and Cultural Dimensions of Health,
  Trans-NIH Program Announcement PA-02-043
• Small Grants Program for Behavioral Research in
  Cancer Control (R03) - PAR-04-020
• Exploratory Grants for Behavioral Research in
  Cancer Control (R21)- PA-04-034

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Training Mechanisms

• Graduate Internships in Health Communicationshttp
  //rex.nci.nih.gov/NCI_CommIntern/CommIntern.htm
• Cancer Prevention Fellowship Programhttp//www.ca
  ncer.gov/prevention/pob/
• NCI Summer Curriculum in Cancer
  Preventionhttp//www.cancer.gov/prevention/pob/co
  urses/
• Cancer Research Training, Career Development and
  Education Opportunities http//cancertraining.nci.
  nih.gov/

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Emerging Research Issues Potential
Reduced-Exposure Products (PREPs)

• TESTING TOBACCO PRODUCTS PROMOTED TO REDUCE HARM
• Objective to stimulate multidisciplinary
  research on the chemical composition, behavior of
  use, exposure to toxic agents, addictive
  properties, differential toxicity, and individual
  and public health impact of potential
  reduced-exposure tobacco products.

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For more info

• Mark Parascandola
• paramark_at_nih.gov
• 301-496-8584
• www.tobaccocontrol.cancer.gov
• Grants-OER Home Page
• grants.nih.gov/grants/oer.htm
• Everything you wanted to know about the NCI
  Grants Processbut were afraid to ask
• www3.cancer.gov/admin/gab/index.htm