Complexity in Bioprocess Systems

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Complexity in Bioprocess Systems

• Gary Montague
• CEAM

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Simplified Process Overview
Batch Operation
Fermentation stages
Continuous Operation
Cooling and storage
Extraction, drying and packaging
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Why is it difficult?
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Challenges faced

• Diverse data structures
• High dimensional data
• Non-linearity
• Uncertainty
• Dynamic relationships shifted in time
• Changing correlation structures
• Multi-unit operation
• Data corruption

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Research Focus

• Obtaining information
• sensor development
• novel signal interpretation
• the conjunction of data from multiple sources
• process analytics and control technologies for
  the progressive scaling of manufacturing
  processes
• Interpreting the information
• data compression methods
• modelling primarily from a data perspective
• Using the information for improvement
• decision making / control

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Only part of the story
ProblemAssessment
BenefitsAnalysis
Identification ofDataRequirements
MethodSelection
ExploratoryDataAnalysis
Implementation
Performance Assessment