Jacqueline van Engelen and Thanos Arvanitis

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Jacqueline van Engelen and Thanos Arvanitis

• Global Consumer Exposure Modelling Network
• Scenario Development Workshop

ISEA 2005 Tucson, Arizona
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JRC, Ispra Lago Maggiore Intra, Italy
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Exposure Scenarios

• Follow up on the exposure data workshop June 20
  24, Ispra
• (Almost) the same participants
• Participants
• Europe, USA, Canada, Japan
• Regulatory Authorities, Industry, Academia

Ruimte voor plaatsing submerk
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List of participants

• From JRC
• Frans Christensen (ECB)
• Yuri Bruinen de Bruin (PCE)
• Pertti Hakkinen (PCE)
• Kimmo Koistinen (PCE)
• Demosthenes Papameletiou (PCE)
• Alexandre Zenie (PCE)

• Conrad Flessner (US EPA)
• William Gulledge (ACC)
• Yishihide Matoba (Sumitomo, Japan)
• Bette Meek (Health Canada)
• Roger Sutcliffe (Health Canada)
• Chris Money (Exxon, CEFIC)
• Kaori Murasawa (Mitsubishi Chemical Safety
  Institute Ltd, Japan)
• Muhilan Pandian (Infoscientific.com)
• Paul Price (The Lifeline Group Inc)
• Carlos Rodriguez (Procter Gamble)
• Linda Sheldon (US EPA)
• Tipton Tyler (Health Studies Management
  Consulting)
• Joop Van Hemmen (TNO)

• Moderator
• Jacqueline van Engelen (RIVM)
• Organisers
• Stylianos Kephalopoulos (JRC, PCE)
• Athanasios Arvanitis (JRC, PCE, Rapporteur)

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Agenda Exposure Scenarios

• Overview on exposure scenarios in Europe
• REACH
• EISChemRisks
• Overview on exposure scenarios outside Europe
• EPA
• Health Canada
• Industry
• Discussion introduced via presentation
• Exposure scenarios view from exposure assessor
• Link from scenarios to models
• Level of detail
• Example using EIS-ChemRisks toolbox

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Exposure scenarios

• Goal identification and prioritization of
  scenarios
• Overview on
• different frameworks
• different models
• different initiatives
• Level of detail
• Revealed need for
• Common definitions
• Coordination / cooperation between agencies

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Impressions

• Everyone has his or her own perception of what is
  important
• Framework can have own definitions
• The question or issue addressed by the scenario
  helps determine the level of detail

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An Example of the Challenges of Consumer Product
Risk Assessment The Many Possible Uses and
Types of Exposures for a Hand Dishwashing Product
Washing dishes, glassware, and utensils by
hand Soak dishes in sink, or wash under
running water? Wash with or without gloves?
Wash hard surfaces in home (windows, counter
tops, floors, walls, etc.) Wash with or without
gloves?
Accidental eye, skin, and inhalation exposures
Wash the car and other outside surfaces Wash
with or without gloves?
Mixing with other products for cleaning
Ingestion of the products chemicals left on
dishes, glassware, and utensils
Novel uses, e.g., put into a spray bottle for
cleaning tasks
Wash hands, hair, and pets
Slide designed by Bert Hakkinen
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Some examples

• REACH own definition of exposure scenario
  (includes risk management)
• RIVM factsheets
• EIS-ChemRisks proposed standard exposure scenario
  format
• US-EPA

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REACH

• Exposure scenario Key outcome of chemical safety
  assessment
• Includes risk management measures
• Have to be communicated to downstream users, but
  at the moment, does not foresee any feedback from
  the downstream user
• One set of conditions for environment and human
  health
• Current discussions how broad/narrow the
  scenarios should be

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EISChemRisks

• European Information System on Risks from
  chemicals released from consumer
  products/articles A scenario based exposure
  assessment approach
• Key data sources a.o. public and industrial risk
  assessments
• Indexing data according to standard taxonomies
• Standard format for building and assessing
  exposure scenarios
• The EIS-ChemRisks standard scenario-based-exposur
  e-assessment-dossier format is proposed as a
  common tool to harmonise the exposure assessment
  practices of various policies (such as GPSD and
  REACH).

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(No Transcript)
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RIVM Factsheets

• Collection of default parameters for exposure
  scenarios to be used in the ConsExpo software
  program
• Products are grouped according to their exposure
  characteristics
• All relevant information needed for exposure
  assessment
• Use, general composition, remarks etc
• For all subcategories
• Default models with default parameters
• Aim to describe use of all products within a
  subcategory using standard models and parameters
• Product specific (but not chemical specific)
  scenario

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US EPA

• Conclusion Drivers for model evolution
• Science and technology
• Methods and data
• Instrumentation Computing hardware/software
• Policy
• PERCEIVED NEED
• Assessment quality/operation requirements
• Distribution/accessibility/update schedule
• Managers
• Expertise and interest
• Duration
• Budget

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Level of detail

• What determines level of detail in exposure
  scenario
• Purpose
• Question
• Resources and time
• More details can lower confidence
• Conservative assumptions can minimize complexity

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Links between scenarios and models

• A thousand scenarios can be assessed by a few
  assessment methods, a few algorithms
• Different existing models must be mapped out to
  the different purposes of exposure assessments
• A scenario inventory must start by common
  scenarios among models

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Conclusions

• Complex area
• There is not really a difference in exposure
  scenarios between US/Canada/Europe
• More collaboration is recommended between
  Regulatory Authorities, Industry and Academia
• Scenario based assessments are important tools
• During the workshop is was not possible to list
  scenarios for model comparison

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Recommendations

• To identify scenarios for model comparison
• identify all relevant models for consumer
  products (listed in the JRC Global CEM Net dB
• Identify Exposure Scenario that can be used in
  all models selected
• Perform model evaluation/comparison
• Test model predictions
• Dont underestimate such an exercise!

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Innovative application of detergent powder
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But dermal scenario has to be included
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• Thank you for your
• attention!
• (hope you are still there..)