Dartmouth Brain Imaging Laboratory

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DartmouthBrain Imaging Laboratory Indiana
UniversityCenter for Neuroimaging
http//synapse.hitchcock.org

• Site PI Andrew J. Saykin, Psy.D.

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Research Team

• Andrew Saykin, Psy.D.
• Robert Roth, Ph.D.
• Laura Flashman, Ph.D.
• Thomas McAllister, M.D.
• Nancy Koven, Ph.D.
• Jo Cara Pendergrass, Ph.D.
• John West, M.S.
• Heather Pixley, B.A.
• John MacDonald, M.A.
• Tara McHugh, M.A.

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BIL Impact on NAMIC
Provide Data (structural, functional, and
diffusion MRI) Diffusion Data (1.5T) 6
Healthy controls (HC, older adults) 14
healthy controls and 13 patients with
schizophrenia Structural Data (SPGR volumes,
1.5T) 6 healthy older adult controls
15 patients with schizophrenia volumes plus 8
frontal subregions (left right) Functional
Data (1.5T) - Auditory-verbal n-back
Working Memory Task 20 patients with
schizophrenia, 20 healthy controls -
Verbal Episodic Encoding/Recognition Task
6 healthy older adult controls 14 patients with
schizophrenia, 9 healthy controls 3T Sample
DTI, structural functional MR data on the same
participants Influencing tool and algorithm
design based on User feedback (e.g., 3D Slicer
Editor, DTI module, fMRI module, user
interface)Study demands (e.g., Multi modality
integration, automated gray matter
parcellation) Testing tools and algorithms
developed within NAMIC
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Interactions with Cores 1 2
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Examples of NAMIC Success Stories
Tracing of Multiple Gray Matter Structures
Multi-modality Correlation of Structure and
Function
Left Hippocampus
Right Hippocampus
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Publications and Presentations
NA-MIC Enabled Journal Articles Flashman, L.A.,
Roth, R.M., Cleavinger, H.B., Pixley, H.S.,
McAllister, T.W., Saykin, A.J., Vidaver, R.M.
(in press). Cavum septum pellucidum in
schizophrenia Symptom and neuropsychological
correlates. Psychiatry Research Neuroimaging.
Roth, R.M., Saykin, A.J., Flashman, L.A.,
Pixley, H.S., West, J.D., Mamourian, A.C. (in
press). Event-Related fMRI of Response
Inhibition in Obsessive- Compulsive Disorder.
Biological Psychiatry. McHugh, T.L., Saykin,
A.J., Wishart, H.A., Flashman, L.A., Cleavinger,
H.B., Rabin, L.A., Mamourian, A.C., Shen, L. (in
press). Hippocampal Volume and Shape Analysis
in an Older Adult Population. The Clinical
Neuropsychologist.
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Publications and Presentations
Journal Articles cont. Wishart, H.A., Saykin,
A.J., McAllister, T.W., Rabin, L.A., McDonald,
B.C., Flashman, L.A., Roth, R.M., Mamourian,
A.C., Tsongalis, G.J., Rhodes, C.H. Regional
brain atrophy in cognitively intact adults with a
single APOE epsilon4 allele. Neurology.
67(5)834-42, Sept. 12, 2006. Saykin, A.J.,
Wishart, H.A., Rabin, L.A., Santulli,
R.B., Flashman, L.A., West, J.D., McHugh, T.L.,
Mamourian, A.C. Older adults with cognitive
complaints show brain atrophy similar to that of
amnestic MCI. Neurology. 67(7)1221-4, Oct.
10, 2006. Roth RM, Koven NS, Randolph JJ,
Flashman LA, Pixley HS, Ricketts SM, Wishart HA,
Saykin AJ. Functional magnetic resonance imaging
of executive control in bipolar disorder.
Neuroreport. 17(11)1085-1089, July 31, 2006.
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Publications and Presentations
Submitted Articles Roth, R.M., Koven, N.S.,
Pendergrass, J.C., Flashman, L.A., Saykin, A.J.
(submitted). Apathy and the processing of
novelty in schizophrenia. Koven, N.S., Roth,
R.M., Pendergrass, J.C., Flashman, L.A.,
McAllister, T.W., Saykin, A.J. (submitted).
Contribution of semantic clustering strategy to
verbal learning and memory in schizophrenia.
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Publications and Presentations
Abstracts and Conference Proceedings West, J.,
Saykin, A., Roth, R., Flashman, L., Koven, N.,
Pendergrass, J.C., Arfanakis, K. (2007).
Hippocampal and frontal memory circuitry
abnormalities in schizophrenia Relation of
diffusion, morphometric and fMRI
markers. Submitted to the 13th Annual Meeting of
the Organization for Human Brain Mapping,
Chicago, June. Flashman, L.A., Roth, R.M.,
McAllister, T.W., Pendergrass, J.C.,
Garlinghouse, M.A., Saykin, A.J. (2007).
Dissociation of awareness of different components
of illness in schizophrenia. Poster to be
presented at the 18th Annual Meeting of the
American Neuropsychiatric Association, Tucson,
February. Koven, N.S., Roth, R.M., Buzzuto, L.,
Pendergrass, J.C., Flashman, L.A., Saykin, A.J.
(2007). Impact of reaction time variability on
brain activation during working memory in
schizophrenia. Poster to be presented at the 35th
Annual Meeting of the International
Neuropsychological Society, Portland, February.
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Publications and Presentations
Abstracts and Conference Proceedings cont. Roth,
R.M., Flashman, L.A., Koven, N.S., Pendergrass,
J.C., Garlinghouse, M.A., McAllister, T.W.,
Saykin, A.J. (2007). Subjective integrity of
working memory is related to brain activation
during an N-back task in schizophrenia. Poster to
be presented at the 18th Annual Meeting of the
American Neuropsychiatric Association, Tucson,
February. Koven, N.S., Roth, R.M., Flashman,
L.A., Randolph, J.J., Pixley, H.S., Ricketts,
S.M., Wishart, H.A., Saykin, A.J. (2006).
Relationship between mood and brain activation
during executive control in bipolar I disorder
Poster presented at the 34th Annual Meeting of
the International Neuropsychological Society,
Boston, February. Proceedings of the 34th Annual
Meeting of the International Neuropsychological
Society, 230. Rosen, A., Roth, R.M., Wishart,
H.A., McDonald, B.C., Mac Donald, J., Flashman,
L.A., Fadul, C., Kasper, L., Mamourian, A.,
Saykin, A.J. (2006). Fornix volume in
relapsing-remitting multiple sclerosis.
Proceedings of the 34th Annual Meeting of the
International Neuropsychological Society.
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NAMIC Impact on the BIL

• General Impact
• Join a new network of computer science and
  engineering collaborators
• Opportunity as clinical neuroscience
  investigators to help steer the development of a
  major toolkit and gain a detailed appreciation of
  the tool development process
• New or enhanced interactions with other teams of
  clinical investigators working on multimodality
  neuroimaging studies in relationship to genetic
  and phenotypic variables
• Training Dartmouth --gt Bates, BYU, CUNY, ECSU
  now IU

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NAMIC Impact on the BIL

• Specific Impact
• New platform for morphometric analyses and ROI
  demarcation (Slicer 3 will permit replacing
  legacy tools with future-oriented platform)
• DTI processing pipeline for new 3T data -
  much faster than previous software/approach
• - integration of tractography with other
  modalities
• Integration of fMRI and DTI connectivity data -
  Path of Interest (POI) algorithm/implementation
• Potential for automated segmentation of deep
  gray matter structures using EM-segmenter

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Future Impact of NAMIC

• Lasting impact at Dartmouth, Indiana University
  and destinations of post-doc training program
  graduates
• Extension of NAMIC collaborations via new grant
  proposals currently in planning stages
• Application of NAMIC tools to molecular imaging
  data sets and translational research including
  small animal imaging
• Application to clinical problems including
  surgical planning
• Application of Slicer to render physical 3D
  models for training and potential use in
  treatment planning