CHARISMA: Summary, contd

1
CHARISMA Summary, contd

• Symptomatic patients experienced a 12 reduction
  in the primary end point (significant) with no
  significant increase in severe bleeding
• Asymptomatic patients experienced a 20 increase
  in the primary end point (nonsignificant) with no
  significant increase in severe bleeding
• Overall, clopidogrel plus aspirin was not
  significantly more effective than aspirin alone
  in reducing the primary end point

Bhatt DL et al. N Engl J Med. 20063541706-17.