Shape Analysis and Cortical Correspondence

1
Shape Analysis and Cortical Correspondence

• Martin Styner
• Core 1 (Algorithms), UNC
• Ipek Oguz, Xavier Barbero, Nicolas Augier

2
UNC Core changes

• UNC core split in half
• DTI research move with Guido to Utah
• Shape and Structural research at UNC
• UNC NA-MIC Papers 2007
• Shape
• Cates J, Fletcher PT, Styner MA, Shenton M,
  Whitaker R, Shape Modeling and Analysis with
  Entropy-Based Particle Systems, Information
  Processing in Medical Imaging 2007, 20333-45.
• Styner M, Xu SC, El-Sayed M, Gerig G,
  Correspondence Evaluation in Local Shape Analysis
  and Structural Subdivision, IEEE Symposium on
  Biomedical Imaging ISBI 2007, 1192 - 1195
• Nain D, Styner M, Niethammer M, Levitt JJ,
  Shenton ME, Gerig G, Bobick A, Tannenbaum A,
  Statistical Shape Analysis of Brain Structures
  Using Spherical Wavelets, IEEE Symposium on
  Biomedical Imaging 2007, 209 - 212
• Zhou C, Park DC, Styner M, Wang YM, ROI
  Constrained Statistical Surface Morphometry, IEEE
  Symposium on Biomedical Imaging ISBI 2007, 1212 -
  1215
• M. Styner, I. Oguz, S. Xu, D. Pantazis, and G.
  Gerig. Statistical group differences in
  anatomical shape analysis using hotelling T2
  metric. In Proc SPIE Vol 6512, Medical Imaging,
  2007, pp. 65123Z-1 - 11.
• Kubicki M, Styner M, Markant D, Dreusicke M,
  Kikinis R, McCarley R, Shenton M.
  Interhemispheric connectivity and
  schizophrenia-diffusion tensor imaging study.
  Schizophrenia Bulletin (2007) vol. 33 pp. 340-340
• Evaluation/Validation
• van Ginneken B, Heimann,T, Styner M, 3D
  Segmentation in the Clinic A Grand Challenge,
  Workshop at Medical Image Computing and Computer
  Assisted Intervention, MICCAI 2007, pp. 7-15,
  2007.

3
Slicer 3 Development

• UNC shape analysis tool in Slicer 3
• Modules for individual steps
• High level tool select datasets and go
• ToDo QC, GLM stats, MDL support
• BatchMake/Condor
• UNC Kitware
• Shape Analysis
• Brain segmentation

4
Shape Analysis

• Collaborations UNC, Utah, UIllinois, GT, BWH
• 1 IPMI, 3 ISBI, 1 SPIE and 2 clinical in prep
• Main research on GLM MANCOVA support
• UNC Autism shape analysis Multi-object,
  longitudinal
• New application for shape Orthodontics

5
Cortical Correspondence

• Motivation Cortical analysis of brain measures
• Cortical thickness in Autism
• fMRI analysis
• Goal local cortical correspondence
• Approach
• Population based correspondence
• Entropy minimization with particles on inflated
  surfaces
• Features from original surface
• Sulcal depth, surface location
• UNC Utah

6
Cortical Correspondence

• Prototype software test on 10 control datasets
• Better matching of sulcal features than
  freesurfer
• ISBI submission
• Next Incorporation of additional anatomical
  features
• Connectivity via DTI
• Vessel proximity via MRA
• Probabilistic connectivity
• MIT (Golland, Ngo)

7
Evaluation/Validation

• Tools data for segmentation evaluation
• Caudate liver seg.
• Including NAMIC data
• Workshop MICCAI 07
• Success, positive feedback
• With UUtrecht and DKFZ
• Continued evaluation on web cause07.org
• MICCAI 08 MS lesion seg