Research Program Integration

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Research Program Integration

• Barbara D. Boyan
• Deputy Director for Research
• Georgia Tech/Emory Center for the Engineering of
  Living Tissues

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Research Program Overview

• GTEC uses a systems approach to develop core
  enabling technologies for implementing tissue
  engineering solutions clinically, and as
  appropriate, to provide off-the-shelf tissue
  engineered medical products.
• (Strategic Plan Goal 2)

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GTECs Strategy
Integration into Living Systems
Cell Technology
Construct Technology
Applications
Discovery

• Engineering
• Immune
• Acceptance
• Pre-clinical
• In Vivo Models
• Noninvasive In
• Vivo Imaging

• Biomaterials/
• Scaffolds
• Biomechanical Model Systems
• Biomechanics
• Bioreactors
• Cryopreser-vation
• In Vitro Imaging
• Mathematical Modeling of Tissue Behavior

Tissue Engineered Substitutes and/or Strategies
for Tissue Regeneration Engineered Model Systems
for More Physiologic In Vitro Studies of Basic
Biology

• Embryonic Stem Cells
• Adult Stem Cells/MAPCs
• Gene Therapy
• Bioinformatics and Databases

Tools Made Available by the Biological Revolution
and Advances in Engineering Science and
Technology
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Programmatic Thrusts address application of GTEC
technologies to clinical problems.

• Cardiovascular Substitutes
• Orthopaedic Tissue Engineering
• Metabolic and Secretory Organs
• Neural Tissue Engineering

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Cell Technologies
Steve Stice
Tissue Production, Evaluation and Preservation
Construct Technologies
Andres Garcia
Tim Wick
Integration Into Living Systems
Michelle LaPlaca Elliot Chaikof
Cross-cutting Groups
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Charge to Programmatic Directors and
Cross-cutting Group Coordinators
Programmatic Directors
Cross-cutting Coordinators

• Define target systems
• Identify system requirements
• Develop research program that addresses system
  requirements using 3-plane approach

• Identify advances in technology
• Share expertise across programmatic thrusts
• Seminars, workshops, conferences, databases
• Assess resources to optimize use of new
  technologies
• Equipment, core facilities, personnel

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Programmatic Thrusts and Cross-cutting Groups
Research Council

• Programmatic thrust directors coordinators of
  cross-cutting groups
• Ensure that advances in basic knowledge, enabling
  technologies are rapidly and efficiently
  incorporated into all programmatic thrusts
• Provide a comprehensive and integrated approach
  for tissue engineering in each programmatic
  thrust
• Optimize use of resources
• Address critical needs
• Personnel
• Equipment
• Technology and Training

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CCGs enhance Year 07 activities of the
Programmatic Thrusts

• Cell technologies database
• Bioreactor technologies database
• Biomechanical Testing Laboratory
• Embryonic stem cell core facility at Emory
• Training in embryonic stem cell technology
• Microarray supplements for GTEC projects
• TPEP New Biology Toolbox at Hilton Head meeting
• 324,870 investment in CCG initiatives

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Evolution of the CCG and Research Council

• Bioreactors group restructured as TPEP
• Integration into Living Systems integrated into
  the Research Council
• Two-step review of research program
• Overview of program as a full council
• Budget recommendations by Programmatic Thrust
  directors