something about positive selection on amino acids substitutions - PowerPoint PPT Presentation

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something about positive selection on amino acids substitutions

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Mendelian phenotypes. Homo sapiens. Kondrashov, 2003. 1 per genome. 100 ... rates at 20 human loci where loss-of-function mutations cause Mendelian diseases. ... – PowerPoint PPT presentation

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Title: something about positive selection on amino acids substitutions


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Conflicting True trees
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Possible resolution Eukaryotes are a fusion
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from M. Sogin
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Data on mutation rates
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Data on mutation rates
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Data on mutation rates at 20 human loci where
loss-of-function mutations cause Mendelian
diseases. Because mutations occur regardless of
their impact on fitness, these data probably also
describe the rate of occurrence of beneficial and
neutral mutations.
Kondrashov Hum Mutat 2003
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109bp
http//www.genomesize.com
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Petrov et al. Science 2000
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Drosophila
Laupata
Petrov et al. Science 2000
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Petrov et al. Theor Pop Biol 2002
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Petrov et al. Theor Pop Biol 2002
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