Very Different Receptors for similar viruses: Retroviruses

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Very Different Receptors for similar viruses
Retroviruses
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Similar Receptors for very Different Viruses gt
IG-like domains
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Viral Receptors - IntegrinsIntegral Membrane
proteins
An Alpha Chain (1 of18) A Beta Chain (1 of 8) A
3D Integrin heterodimer Many Integrins bind to
an RGD motif on other extracellular proteins and
provide a signal across the membrane. Viral
attachment proteins can bind here. e.g., some
Adenoviruses bind to AlphaV , and some
Herpesviruses bind AlphavBeta3
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The Influenza HA (Hemagglutinin)Conformational
change to achieve penetration
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HIV
Virus binding Conformational Change in
gp120 Cell and Virus membranes pulled together
HIV Binding / Penetration