CHIC DNA Repository

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CHIC DNA Repository

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CHIC DNA Repository

• MISSION
• The CHIC DNA Repository, co-sponsored by the OFA
  and the AKC CHF, collects and stores canine DNA
  samples along with corresponding Genealogic and
  Phenotypic information to facilitate future
  research

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CHIC DNA Repository

• OBJECTIVES
• Facilitate more rapid research progress by
  expediting the sample collection process
• Provide researchers with optimized family groups
  needed for research
• Allow breeders to take advantage of future DNA
  based disease tests as they become available
• Foster a team environment between breeders and
  the research community improving the likelihood
  of genetic discovery

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CHIC DNA Repository

• AKC Delegates Meeting, Sept 05
• Dr. Elaine Ostrander, AKC DNA Consultant, answers
  questions from the floorBesides money, what is
  the most important thing we can do to assist
  research efforts
• Response PROVIDE SAMPLES

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CHIC DNA Repository

• Need for Education re DNA
• AKC DNA Program
• Imports
• Field Inspections
• Multiple Sired Litters
• Frequently Used Sire
• Parentage Verification / Stud Book Integrity
• Versus DNA for Health Research Purposes

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CHIC DNA Repository

• Blood versus Swab Solution
• Blood
• Higher Yield
• Better Quality
• Works with all scientific applications
• Invasive
• High Cost
• Limited Participation
• Swabs
• Low Cost
• Non Invasive
• Greater Participation
• Decreased Yield
• New Technology requires less quantity

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CHIC DNA Repository

• Dual SolutionBlood or Swab
• Blood
• University of Missouri, Dr. Gary Johnsons Lab
• Swabs
• University of California Davis, Veterinary
  Genetics Lab, contacts Dr. Mark Neff Dr.
  Alison Ruhe

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CHIC DNA Repository

• Pilot Program
• 6 Months
• Golden Retriever Club of America
• Sample, Genealogy, Health History collected on
  nearly 1,000 dogs
• Mix of healthy / affected dogs
• Heart Murmurs, Hemangiosarcoma, Fibrosarcoma,
  Mast Cell Tumors, Hypothyroid, Cataracts, Hip
  Elbow Dysplasia

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CHIC DNA Repository

• 24 Months Later
• 3000 dogs
• 60 breeds
• 2 approved application for samples
• MBT Lens Luxation
• GR Mast Cell Tumor
• 4 clubs have facilitated transfer of samples from
  existing banks to CHIC (Miniature Bull Terriers,
  Otterhounds, Field Spaniels, Poodles)
• National Specialty DNA Clinics

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• Contact Info
• Eddie Dziuk, OFA, edziuk_at_offa.org (573)
  442-0418 x222
• Erika Werne, AKC CHF, eaw_at_akcchf.org (888)
  682-9696

• Questions?