VIREAD tenofovir disoproxil fumarate

1

Initiation of Antiretroviral Therapy Is Once
Enough?
Michael S. Saag, MD
MS Saag, MD.Presented at IASUSA/RWCA Clinical
Conference, August 2004.
The International AIDS SocietyUSA
2
When to Start Recommendations for Initiating
Therapy
Yeni et al, for IASUSA. JAMA, 2004.
3
Changing Treatment Guidelines DHHS Asymptomatic
patients
ltwww.aidsinfo.nih.govgt
4
AIDS free survival by log HIV-1 RNA at baseline

1.00
lt3
3-3.99
0.95
4-4.99
0.90

Probability of AIDS free survival

gt5
0.85
0.80
0.75
0
1
2
3
Years from starting HAART
5
Initial Regimens

• Generally Recommended
• NNRTI 2 NRTIs
• Boosted PI 2 NRTIs
• Generally NOT Recommended
• 4-drug regimens
• 3-NRTI regimens, except when NNRTI and PI use is
  precluded
• 2-drug regimens or monotherapy (eg, 1 PI)

6
FTC-301 Efficacy Endpoints at Week 48
Saag et al, JAMA, 2004.