Pharmacology

1
Pharmacology

• Science that studies interactions of drugs with
  organism on different levels (subcellular,
  cellular, organ, systemic)
• Studies
• relationship between chemical structure and
  biologic activity
• site of effect localisation
• mechanism of action
• fate of drug in organism
• evaluation of relationship between dose and
  biologic effect

2
Clinical pharmacology

• is the science of drugs and clinical use of drugs
• branches
• pharmacodynamics
• pharmacokinetics
• rational prescribing
• adverse drug effects
• drug interactions
• toxicology
• drug development

3
Pharmacogenetics

• study of genetic variation which cause different
  response to drugs
• is taking into consideration one or only a few
  genes
• e.g. of genetic variation slow and fast
  acetylators (variation in the N-acetyltransferase
  gene)

4
Pharmacovigilance

• science of collecting, monitoring and evaluating
  information of the adverse effects of
  medications, biological products, herbalism and
  other medicines
• from Greek pharmacon drug
• Latin vigilare to keep alert

5
Pharmacoeconomics

• study that evaluates the cost and effects of a
  drug or drug therapy
• examples of pharmacoeconomic evaluation types
• cost benefit analysis
• cost minimization analysis