University at Buffalo

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VAWNYHS
School of Medicine Biomed. Sciences
University at Buffalo The State University of New
York
Buffalo-Niagara Medical Center
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• FLIESLER, Steven J, PhD  Lipid/sterol
  metabolism photoreceptor membrane trafficking
  animal models of retinal degenerations.
• GONZALEZ-FERNANDEZ, Federico, MD, PhD
  Photoreceptor - RPE interactions vitamin A
  (retinoid) cycle Interphotoreceptor matrix
  structure and function of retinoid binding
  proteins Xenopus and zebrafish model systems
  human ocular pathology.
• MU, Xiuqian, MD, PhD Retinal development
  retinal ganglion cell differentiation gene
  regulatory networks transgenic and knockout
  mouse models.
• PATEL, Sangita P., MD, PhD molecular basis of
  corneal hydration control corneal endothelial
  cell physiology
• REYNOLDS, James D., MD Retinopathy of
  Prematurity (ROP)- multi-center treatment
  trials, CRYO-ROP, LIGHT-ROP, ET-ROP, natural
  history and its implications for screening.
• SULLIVAN, Jack M., MD, PhD  RNA drug discovery
  for retinal/macular degenerations gene
  silencing/gene therapy humanized mouse models of
  retinal degeneration retinal electrophysiology.

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• BAIER, Robert E., PhD  Oral Diagnostic
  Sci./Biomaterials Interfacial biophysics
  structure and function of macromolecules at
  biosurfaces anterior tear film structure
  biomaterials compatibility with ophthalmologic
  contact tissues.
• GOSH, Debashis, PhD HWI X-ray
  crystallographic studies of protein
  structure-function relationships
• MEYER, Anne E., PhD Oral Diagnostic
  Sci./Biomaterials Surface analysis
  biomaterials biofilms/biofouling ophthalmologic
  friction and lubrication.
• SEIGEL, Gail M., PhD Center for Hearing
  Deafness Cancer stem cells retinoblastoma
  retinal cell differentiation. Established the
  R28 rat retinal precursor cell line (available
  for collaborative efforts)
• SLAUGHTER, Malcolm M., PhD Physiology
  Biophysics Information coding in retina role
  of synaptic receptors in synaptic labeled lines.
• TITUS, Albert H., PhD Electrical
  Engineering/Integrated Nanostructured Systems
  Analog VLSI Design, Silicon-based neuromorphic
  visual processing systems, Neural networks,
  Electronic routing and packaging design, Electron
  beam lithography, Sensors, Optoelectronics.

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NIH Grant Support
FUNDED

• FLIESLER, SJ - NIH/NEI RO1 EY007361 Isoprenoid
  Metabolism in the Retina
• NIH/NEI RO1 EY013623 (subaward) Proteasome
  Function in the Aging Retina
• GONZALEZ-FERNANDEZ, F- NIH/NEI R01 EY009412
• Interphotoreceptor Retinoid Binding
  Protein Structure and Function
• SEIGEL, GM- NIH/NEI R21 CA127061
  Tumor-Initiating Cells in Retinoblastoma
• NIH/NCI U54 CA143876 (subaward) Center on the
  Microenvironment and Metastasis
• SLAUGHTER, MM- NIH/NEI R01 EY005725 Synaptic
  Mechanisms in Retina
• NIH/NEI R24 EY016662 UB
  Vision Infrastructure Center
• PENDING
• MU, X- NIH/NEI NIH/NEI RO1 EY020545
  Interaction of Isl1 and Pou4f2 in Retinal
  Development
• SEIGEL, GM- NIH R01 CA138230 (Subaward)
  Immune Targeting of Tumor Stem Cells in
  Retinoblastoma
• SULLIVAN, JM- NIH/NEI R01 EY13433 A
  Ribozyme Rescue Strategy for Autosomal Dominant
  Retinitis Pigmentosa

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• New York State Center of Excellence in
  Bioinformatics Life Sciences  (CoE)
• Hauptman-Woodard Medical Research Institute (HWI)

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• Roswell Park Cancer Institute (RPCI)
• http//www.roswellpark.org/Home
• UB Center for Advanced Biomedical and
  Bioengineering Technology (UBCAT)
•   http//www.bioinformatics.buffalo.edu/cat.php
• UB2020 Integrated Nanostructured Systems
  http//ub2020.buffalo.edu/ins/

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Potential R24/Collaborative Projects

• RNA Drug Discovery for Ocular Diseases
• J. Sullivan, P. Reinach, J. Danias, M.
  Srinivas, and others
• Stem Cell Therapy for Glaucoma
• X. Mu, J. Danias, G. Seigel, and others
• Structural Biology and Molecular Modeling
• F. Gonzalez-Fernandez, D. Gosh, and others
• Animal Models of Dysregulated Metabolism
• S.J. Fliesler, B. Knox, J. Danias, and
  others

More immediate therapeutic development potential