Living organisms put themselves together, all by themselves' No one reads the instructions and tucks - PowerPoint PPT Presentation

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Living organisms put themselves together, all by themselves' No one reads the instructions and tucks

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No one reads the instructions and tucks tab A into slot B. But getting into the ... Molecular Mimicry by Elongation & Release Factors ... – PowerPoint PPT presentation

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Title: Living organisms put themselves together, all by themselves' No one reads the instructions and tucks


1
How Do They Do That?
Living organisms put themselves together, all by
themselves. No one reads the instructions and
tucks tab A into slot B. But getting into the
right shape can't happen just by chance. So where
are the directions? And how do living things
follow them? David Brown, MD, Washington Post
Staff Writer
2
From Information to Function
The cell needs to convert the information
contained in the DNA and encoded in nucleic acid
sequence of the genes into a functional form, and
the functional form is protein.
3
Components Needed for Translation
GTP
4
Ribosome
5
Ribosome
6
Ribosome
riboprotein
rRNA
7
tRNA
III
III
II
IV
IV
I
II
I
8
Getting Started Translation Initiation
9
Peptide Elongation
From Cell vol 108 557-572 (2002)
10
Translation Termination
From Cell vol 108 557-572 (2002)
11
Molecular Mimicry by Elongation Release Factors
It is believed that the similarity in shape of
the elongation and release factors allow them to
mimic the tRNA and occupy the A-site.
12
Translation Animation
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