PHARMACOVIGILANCE ON RABIES IMMUNOGLOBULINS ADMINISTRATION

1
PHARMACOVIGILANCE ON RABIES IMMUNOGLOBULINS
ADMINISTRATION By  Rajan H.
Under the guidance
of Sudharshan M.K., Mahendra B.J., Githa Kishore,
Meera N.K.
Department of Pharmacy Practice Visveswarapura
Institute of Pharmaceutical Sciences Bangalore
2
INTRODUCTION

• DEPARTMENT OF PHARMACY PRACTICE VIPS, BANGALORE

3
DEPARTMENT OF PHARMACY PRACTICE VIPS, BANGALORE
4
DEPARTMENT OF PHARMACY PRACTICE VIPS, BANGALORE
5

• Rabies is essentially a zoonotic disease with man
  being the dead-end host.
• Annual number of deaths caused by rabies
  worldwide as estimated by WHO accounts for 55,000
  and mostly in the rural areas of Africa and Asia.

DEPARTMENT OF PHARMACY PRACTICE VIPS, BANGALORE
6


DEPARTMENT OF PHARMACY PRACTICE VIPS, BANGALORE
7

• Post-exposure prophylaxis adequately applied
  after exposure to a rabid animal is highly
  effective in prevention of human disease.
• Adverse reactions after vaccination are
  considered as an important practical problem.

DEPARTMENT OF PHARMACY PRACTICE VIPS, BANGALORE
8

• Identification of adverse reactions during
  post-exposure prophylaxis of rabies
  immunoglobulins would be helpful in improving the
  quality of life of the recipient and to prevent
  further hospitalization.
• This study is a small step in this direction.

DEPARTMENT OF PHARMACY PRACTICE VIPS, BANGALORE
9
OBJECTIVE
DEPARTMENT OF PHARMACY PRACTICE VIPS, BANGALORE
10

• To find out the various adverse reactions during
  post-exposure prophylaxis of rabies
  immunoglobulins.
• To find out the sociodemographic details of the
  host as well as the carriers.

DEPARTMENT OF PHARMACY PRACTICE VIPS, BANGALORE
11
METHODOLOGY
DEPARTMENT OF PHARMACY PRACTICE VIPS, BANGALORE
12
METHODOLOGY

• A retrospective study was conducted in 1000-bed
  tertiary care teaching hospital, in Rabies
  Preventive Medicine Department, KIMS, Bangalore.
• The data was collected for a period of two and a
  half years from June 2003 to December 2005 based
  on the records and data stored in the department.

DEPARTMENT OF PHARMACY PRACTICE VIPS, BANGALORE
13

• RESULTS
• AND
• DISCUSSIONS

DEPARTMENT OF PHARMACY PRACTICE VIPS, BANGALORE
14

• Overall 1316 cases were analyzed.

DEPARTMENT OF PHARMACY PRACTICE VIPS, BANGALORE
15
RESULTS AND DISCUSSIONS
DEPARTMENT OF PHARMACY PRACTICE VIPS, BANGALORE
16
RESULTS AND DISCUSSIONS
DEPARTMENT OF PHARMACY PRACTICE VIPS, BANGALORE
17
DEPARTMENT OF PHARMACY PRACTICE VIPS, BANGALORE
18
DEPARTMENT OF PHARMACY PRACTICE VIPS, BANGALORE
19
DEPARTMENT OF PHARMACY PRACTICE VIPS, BANGALORE
20
DEPARTMENT OF PHARMACY PRACTICE VIPS, BANGALORE
21
DEPARTMENT OF PHARMACY PRACTICE VIPS, BANGALORE
22
DEPARTMENT OF PHARMACY PRACTICE VIPS, BANGALORE
23
DEPARTMENT OF PHARMACY PRACTICE VIPS, BANGALORE
24
PetStray Ratio is 12.5
DEPARTMENT OF PHARMACY PRACTICE VIPS, BANGALORE
25
DEPARTMENT OF PHARMACY PRACTICE VIPS, BANGALORE
26
DEPARTMENT OF PHARMACY PRACTICE - VIPS, BANGALORE
27
DEPARTMENT OF PHARMACY PRACTICE VIPS BANGALORE
28
DEPARTMENT OF PHARMACY PRACTICE VIPS BANGALORE
29
DEPARTMENT OF PHARMACY PRACTICE VIPS BANGALORE
30
DEPARTMENT OF PHARMACY PRACTICE VIPS BANGALORE
31
DEPARTMENT OF PHARMACY PRACTICE VIPS BANGALORE
32
DEPARTMENT OF PHARMACY PRACTICE VIPS BANGALORE
33
DEPARTMENT OF PHARMACY PRACTICE VIPS BANGALORE
34
DEPARTMENT OF PHARMACY PRACTICE VIPS BANGALORE
35
Chi Square Test For Immediate Reactions
DEPARTMENT OF PHARMACY PRACTICE VIPS BANGALORE
36
Z Test For Proportions
DEPARTMENT OF PHARMACY PRACTICE VIPS BANGALORE
37
Chi Square Test For Delayed Reactions
DEPARTMENT OF PHARMACY PRACTICE VIPS BANGALORE
38
Z Test For Proportions
DEPARTMENT OF PHARMACY PRACTICE VIPS BANGALORE
39
CONCLUSION
DEPARTMENT OF PHARMACY PRACTICE VIPS BANGALORE
40

• The study helps to identify the adverse reactions
  of rabies immunoglobulins so that further
  precautions can be taken by giving proper
  counseling and treatment to improve the quality
  of life of the recipient.
• Since P value is there is a significant relationship between the
  type of vaccines and the immediate reaction.

DEPARTMENT OF PHARMACY PRACTICE VIPS BANGALORE
41
CONCLUSION

• Since the petstray dog ratio is more ie 12.5,
  the stray dog population should be controlled.

DEPARTMENT OF PHARMACY PRACTICE VIPS BANGALORE
42

• THANK YOU

DEPARTMENT OF PHARMACY PRACTICE VIPS BANGALORE