Partnering for Success

1
Partnering for Success
A case study demonstrating how Scopus improves
research productivity at Evotec
2
Tomorrows Drugs Today
Evotec is building a pipeline of drug candidates
for more than 150 partners worldwide including

• From discovery to clinical phases to develop
  novel small molecule drugs applicable to targets
  across all therapeutic areas
• 350 staff (primarily in Hamburg, Germany and
  Abingdon, UK), 100 of which in RD

3
Tomorrows Drugs Today

• Specializes in finding new treatments for
  diseases of the Central Nervous System (CNS)
• Has a product pipeline with candidates at various
  stages of development
• Has established itself as partner for pharma and
  biotech companies by providing high-quality,
  innovative and integrated solutions from drug
  target to clinic
• Offers higher value, results-driven projects by
  sharing in the customers risks and success

4
Partnering for Success
We strive to be the premier drug discovery and
development partner for pharmaceutical and
biotechnology companies
Scopus speeds up the initial phases of the
research process at Evotec by a factor of 2
5
Evotecs main challenges

• As were actively involved as a development
  partner in a program, we need to continuously
  analyze literature to follow up on the progress.
• We sometimes have to develop new experiments
  within an existing program.
• If weve sold a program to a partner company,
  were often contacted by the company to comment
  on questions that came up.
• Were regarded as experts by our partners,
  meaning that we have to be continuously up to
  date so we can deliver high-quality and
  innovative solutions whenever were called upon
  to do so.

6
Meet Andreas Ebneth, PhDGroup Leader, Cellular
Systems

• My RD tasks

Draft experiments and compare results to
published data
Interpret and validate data obtained from
internal programs
Identify promising targets for new drug
development
Act as experts in the field for development
partners
Track competitors and colleagues publications
7
Meet Andreas Ebneth, PhDGroup Leader, Cellular
Systems

• My RD tasks

I use Scopus for
8
Meet Andreas Ebneth, PhDGroup Leader, Cellular
Systems

• My RD tasks

Interpret and validate data obtained from
internal programs
I use Scopus for
9
Meet Andreas Ebneth, PhDGroup Leader, Cellular
Systems

• My RD tasks

Identify promising targets for new drug
development
I use Scopus for
10
Meet Andreas Ebneth, PhDGroup Leader, Cellular
Systems

• My RD tasks

Act as experts in the field for development
partners
I use Scopus for
11
Meet Andreas Ebneth, PhDGroup Leader, Cellular
Systems

• My RD tasks

Track competitors and colleagues publications
I use Scopus for
12
Meet Andreas Ebneth, PhDGroup Leader, Cellular
Systems

• My RD tasks

Draft experiments and compare results to
published data
Interpret and validate data obtained from
internal programs
Identify promising targets for new drug
development
Act as experts in the field for development
partners
Track competitors and colleagues publications
I use Scopus for
Building up expertise quickly and sustaining
this expertise Powerful alert function keeps us
up to date automatically
Routine, ongoing analysis of the
literature Indispensable for monitoring progress
or designing new experiments
Monitoring new publications across multiple
scientific fields Use tools like Citation Tracker
to keep track of breakthroughs and trends
Specific searches for well-known
compoundsdescribed in the literature Compare
with data on new chemical entities essential
information when soliciting potential partners
Initial broad search Scopus data helps me
interpret my initial observations as well as
draft new experiments
13
Meet Heinz von der Kammer, PhDGroup Leader,
Molecular Systems

• My RD tasks

1. Target Identification Help analyze
potential of new drug candidate
2. Build Hypothesis Construct an intensive
literature study around known data
3. Refine Hypothesis From gathering
information to gaining knowledge
4. Lead Identification Step 1 Identify
viable targets for drug development process
5. Lead Identification Step 2 Search patent
files to prove freedom- to-operate status
14
Meet Heinz von der Kammer, PhDGroup Leader,
Molecular Systems

• My RD tasks

1. Target Identification Help analyze potential
of new drug candidate
I use Scopus for
15
Meet Heinz von der Kammer, PhDGroup Leader,
Molecular Systems

• My RD tasks

2. Build Hypothesis Construct an intensive
literature study around known data
I use Scopus for
16
Meet Heinz von der Kammer, PhDGroup Leader,
Molecular Systems

• My RD tasks

3. Refine Hypothesis From gathering
information to gaining knowledge
I use Scopus for
17
Meet Heinz von der Kammer, PhDGroup Leader,
Molecular Systems

• My RD tasks

4. Lead Identification Step 1 Identify
viable targets for drug development process
I use Scopus for
18
Meet Heinz von der Kammer, PhDGroup Leader,
Molecular Systems

• My RD tasks

5. Lead Identification Step 2 Search patent
files to prove freedom-to-operate status
I use Scopus for
19
Meet Heinz von der Kammer, PhDGroup Leader,
Molecular Systems

• My RD tasks

4. Lead Identification Step 1 Identify
viable targets for drug development process
5. Lead Identification Step 2 Search patent
files to prove freedom-to-operate status
2. Build Hypothesis Construct an intensive
literature study around known data
3. Refine Hypothesis From gathering
information to gaining knowledge
1. Target Identification Help analyze
potential of new drug candidate
I use Scopus for
Constructing specific, targeted searches (Scopus
is my primary source of information)
Conducting broad searches across all subject
areas/topics to retrieve all information on this
specific target
Sophisticated tools like Citation Tracker to
extract additional data
Conducting initial broad search on current
patents
Searching for specific assays
20
Why we prefer Scopus over other sources (1)

• Intuitive, easy-to-use platform, no prior
  experience needed. Others, like Ovid, are much
  more difficult to use.
• Faster access to full text.
• Secure server (PubMed hasnt got this).
• Integrated patent search saves a lot of time
  while doing my literature search.
• Easy alerting to keep up to date automatically.

One of the main reasons we switched from Ovid to
Scopus was because Scopus is just so easy to
use.
Integrated patent searching saves me so much
time. I can get an overview of the patent
situation while Im doing my literature search.
I have a specific research interest. The Scopus
alerts deliver articles that are highly relevant
to my research area. You cant get this service
from Ovid.
Because of this, Scopus saves us precious time!
21
Scopus Citation TrackerWhy we prefer Scopus
over other sources (2)
Within PubMed its not as easy to follow the
citation trail or link from citations. And I can
easily set up citation alerts. Ovid hasnt even
got a citation searching option.
One of the best features of Scopus is the
Citation Tracker. Following the citation trail
leads me to key information I might not have
found otherwise. This really adds value for me.

• Scopus Citation Tracker helps us to
• Identify relevant citation patterns on new
  literature search
• Check the most up-to-date citation data on
  specific topics and articles
• Track and evaluate research trends using the
  extensive citation history
• Save time compared with more traditional keyword
  searching

• Using PubMed or Ovid, Im essentially limited to
  just traditional keyword searching.

22
1. Scopus search results keyword Alzheimer
23
2. Results list, sorted on highest number of
Cited Bys for each article
24
3. Selection of highest cited article to view
citation breakdown via the Citation Tracker
25
4. Citation overview with breakdown per year
From here you can click on a specific year, e.g.
2005
26
5. 2005 results
Result The Citation Tracker enables you to delve
deeper into content than by just using
traditional keyword searching leading to the
disclosure of multiple layers of information.
27
The value Scopus has for us

• Scopus helps to gain and keep competitive
  advantage in a fast-moving, highly demanding
  market.

Scopus is very customer friendly and intuitive
and therefore easy to use. It gives a broad view
on literature searching and therefore makes the
whole picture complete.
Scopus is the most convenient database giving the
most comprehensive results in the shortest time.
Scopus speeds up the research process by a
factor of 2, compared to the situation before we
had Scopus available at our company.
Heinz von der KammerGroup Leader, Molecular
Systems
Andreas Ebneth Group Leader, Cellular Systems
28
Evotec and Scopus Partnering for Success

• Scopus saves Evotec time, reduces costs and
  contributes to greater research productivity in
  the early research phase by a factor 2
  accelerating the research process creates a
  competitive advantage
• Scopus provides the complete picture with cross-
  disciplinary searching across every scientific
  and biomedical discipline, disclosing information
  that might not have been found in more
  specialized databases
• Using the Citation Tracker helps Evotec discover
  key information that wouldnt have been found by
  only using the search interface
• Scopus facilitates quick access to full text
• Cross reference citation searching discloses
  related and recent publications