Bez tytulu slajdu

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EU PROJECTS INTERNATIONAL HEREDITARY CANCER
CENTER SZCZECIN - POLAND
J. Lubinski
POMERANIAN MEDICAL UNIVERSITY
Poznan march 10 2004
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IHCC - MISSION

• HEREDITARY CANCERS
• PROPHYLACTICS
• DIAGNOSIS
• TREATMENT

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IHCC - 1992

• The first Polish outpatient clinics for familial
  cancers

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IHCC - 1999

• A few realized earlie international projects by
  IHCC as co-ordinator
• A few dozen of prepared on place SCI publications

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EU 1999

• 5th framework programme
• Ist call for proposals

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IHCC

• I. UICC familial cancer and prevention project
• development of Polish network of outpatient
  clinics for familial cancers

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IHCC

• II. Hypothesis
• Poland (Eastern Europe) is genetically homogenous

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IHCC

• II. Hypothesis
• Poland (Eastern Europe) is genetically homogenous

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DEVELOPMENT OF NETWORK OF CANCER FAMILY SYNDROME
REGISTERIES IN EASTERN EUROPE
EC PROJECT No QLRT 1999-000632000-2002
J. Lubinski
POMERANIAN MEDICAL UNIVERSITY, SZCZECIN, POLAND
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(No Transcript)
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EU PROJECT PARTICIPANTS
1. BOESZE P. BUDAPEST, HUN 2. ELSAKOV
P. VILNO, LITH 3. FORETOVA L. BRNO, CZ
4. GARDOVSKIS J. RIGA, LAT 5. HAITES
N. ABERDEEN, UK 6. MOESLEIN G. DUSSELDORF, GER
7. MECKLIN J-P. HELSINKI, FIN 8. NEUMAN
H. FREIBURG, GER 9. PONDER B. CAMBRIDGE, UK
10. SOBOL H. MARSEILLE, FRA 11. VASEN
H. LEIDEN, HOL 12. WEBER N BASEL, SWITZ AUTOR
AND COORDINATOR 13. LUBINSKI J. SZCZECIN, POL
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SPECIFIC GOALS OF OUR PROJECT

• ELABORATION OF STANDARDS FOR A MODEL CFS
  REGISTRIES IN EASTERN EUROPE
• REGISTRATION OF 2000 FAMILIES WITH DIFFERENT
  TYPES OF CFS IN POPULATIONS OF EAST EUROPEAN
  COUNTRIES
• INITIATION OF EUROPEAN COLLABORATIVE STUDIES WITH
  THE USE OF MATERIAL COLLECTED BY EAST-EUROPEAN
  REGISTRIES

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STANDARDSOF A MODEL REGISTRYOF CANCER
FAMILYSYNDROME
EC PROJECT No QLRT 1999-000632000-2002
www.pam.szczecin.pl/5pr_ue
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EC CFS - REGISTERED FAMILIES
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EC PROJECT No QLRT 1999-00063 2000-2002

• Initiation of 22 international collaborative
  studies

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POLISH FAMILIES WITH STRONG AGGREGATION OF
BREAST/OVARIAN CANCERS (n200)

• BRCA 1 65
• BRCA2 4

Górski B. et al. 2002
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POLISH PANEL OF BRCA1 MUTATIONS

• 5382 ins C
• C 61 G
• 4153 del A

90 of mutations
Górski B. et al. 2002
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BRCA1 MULTIPLEX PCR
possitive controls
patients
4153 delA
5382 insC
5382 insC
(-) DNA
C61G
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BRCA1 FOUNDER MUTATIONS IN POLAND

• GÓRSKI B. ET AL. - PATENT NO P335917- MULTIPLEX
  PCR - 50

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BRCA1 REGISTRY SZCZECIN POLAND
2150 CARRIERS
THE LARGEST REGISTRY IN THE WORLD
Szczecin February 2004
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MSH2 / MLH1 RECURRENT MUTATIONS IN POLAND

• OF ALL OF MUTATIONS
• MSH2/SD5 A ? T 9423 19
• MLH1/18 2041G ? A 16

G. Kurzawski et al. IHCC Szczecin
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6th FRAMEWORK EU PROGRAMME2004
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3 PROJECTS IHCC CO-ORDINATOR
I. Development of network of cancer family
syndrome registries in Balcan States
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3 PROJECTS IHCC CO-ORDINATOR

• II. Development of network of cancer family
  syndrome registries in Eastern Europe
• 37 participants from 16 countries

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3 PROJECTS IHCC CO-ORDINATOR
III. Identification of new cancer susceptibility
genes by linkage analyses in Polish families with
aggregation of breast or colorectal cancers
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LIN ANAL FAM AGGR BREAST COLON CA GENES
2004-2006
EU PROJECT
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More information

• www.genetyka.com
• e-mail ihcc_at_wp.pl
• phone [phone]fax [phone]