B Vitamin analogs & synthetic methods. Analogs of a

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B Vitamin analogs synthetic methods
Analogs of a B Vitamin (Nicotinamide Riboside)
that act on Sirtuin pathways and efficient,
stereoselective methods to synthesize
Inventor Anthony Sauve, PhD Assistant
Professor of Pharmacology
Leader in the study of sirtuin biochemistry.
Co-inventor on key sirtuin patents.
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B Vitamin analogs synthetic methods
Markets
B vitamins (dietary supplement) 200M Cardioprot
ection in acute MI (drug) 1.3B Neuroprotection/
anti-aging (drug) 1B Alleviate drug toxicity
(e.g. statins) ?? Cancer 15B total
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B Vitamin analogs synthetic methods
The recent discovery of the sirtuin family of
enzymes has generated enormous scientific and
commercial excitement

• Sirtuins are the apparent target of resveratrol
• Sirtuins appear to be the long-sought biochemical
  agent responsible for the effects of caloric
  restriction a dietary regime known to
  drastically retard aging (effect discovered at
  Cornell in 1934)

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• Sirtuins are HDACs - they deacetylate proteins in
  a reaction that consumes nicotinamide adenine
  dinucleotide (NAD).
• Cells produce NAD from niacin (the primary B
  vitamin), and use it to transport electrons in
  the citric acid cycle the basic process of
  cellular respiration.
• In the course of investigating sirtuin
  biochemistry, Prof. Sauve has been part of a
  group of investigators re-invigorating the study
  of B vitamins and NAD metabolism.
• Increasing intracellular NAD levels can improve
  or preserve the health of a cell.
• Compounds that poison NAD metabolic pathways can
  be toxic two cancer drugs on the market do so
  tiazofurin and benzamide riboside

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Nicotinamide Riboside (NR)
NR was found in milk in 1950s the enzyme that
converts NR to NAD not found until 2000s -- NR
is a vitamin. No NR on market as dietary
supplement
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Until now, there has been no cost-efficient
method to synthesize NR.

• Scalable, one pot, high-yield method
• Can stereoselectively synthesize NR and control
  creation of derivatives
• Novel derivatives generated
• Cell protective
• Cell killing

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• Developmental status
• Novel compounds generated
• in vitro testing underway
• Intellectual Property
• US and PCT patent applications pending
• Availability
• Exclusive licenses available by field-of-use