Immune System Review Book

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Immune System Review Book

• Fold a blank piece of paper into 8 rectangles,
  then cut them apart. Staple the pages together
  to make a booklet.

Immune System Review Book
staples
The purpose of the book is to give you an
overview/summary of the Immune system. Use it to
help you study!
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Immune System Review Book
Cover of book

• By _________________

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Inside cover (first pages)
Left side right side

• 1. Surface Barriers

• The Three Lines of Defense
• Surface Barriers
• Nonspecific Response
• Specific Response

Skin Tears Mucous Membranes Saliva Cough
Sneeze Friendly Bacteria Low pH Urine Diarrhea
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Next pages

• Cascade Lysis

• Non-specific Response
• Complement Proteins Can interact with carb
  molecules on the surfaces of microorganisms

Attack complexes insert into cell membrane and
lyse microorganism (death)
Reactions to make protein membrane attack
complexes
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Next Pages (Im sorry I forgot these in class
Wednesday! You can add them to the end of your
booklet if it is too hard to insert them)

• 2. Inflammatory Response also non-specific

d. Complement proteins attack bacteria
a. Bacteria invade
b. Tissue irritation causes mast cells to
release histamine (shown here as red dots)
e. Phagocytes engulf invaders
c. Capillary walls become leaky. Fluid and
complement proteins leak out. Swelling.
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• Specific Response
• Antigen triggers formation of lymphocyte armies.

• T and B lymphocytes will specifically recognize
  FOREIGN antigens.
• T and B will divide repeatedly into effector and
  memory cells.
• Our own cells recognize each other. Cells have
• MHC markers designating self.

antigen on surface of bacterial cell
antigen on surface of virus
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• 3. T Cell Mediated Response

• T cell Receptor of Helper T cells recognize the
  specific MHC-antigen complex. Binding stimulates
  the macrophage to secrete interleukins.
• Helper T releases interleukin 2.
• Interleukin 2 stimulates cell division of
  effector cytotoxic T armies

Antigen-MHC Complex
a. Macrophages ingest virus particles. Virus
antigens are not digested, ANTIGEN IS DISPLAYED
IN MHC COMPLEX
Effector cytotoxic T What does cytotoxic T do?
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• Antibody-mediated response (B cells)
• Antibody

Effector Cytotoxic T cells find body cells
infected with the virus (virus antigen presented
in antigen-MHC complex). They touch kill cells
with perforins.
antigen-binding sites
antigen-MHC complex on infected body cell
effector cytotoxic T cell
touch-killed body cell
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last pages

• B cell armies are made

3. Antibody-mediated response
B cell encounters unbound Antigen from bacteria.
Receptors bind antigen. Antigen is displayed in
MHC.
Helper T binds to antigen-MHC. Interleukins are
released. Interleukins trigger cell division B
cell armies are made.
Effector B cells Make/secrete many antibodies
Memory B cells are made, too