Cationp Interactions is Chemistry and Biology.

1
Cation-p Interactions is Chemistry and Biology.
Dougherty, D. A. Science, 1996, 271, 163.Chem.
Rev. 1997, 97, 1303-1324.
Craig's presentation on quadrapoles Acc. Chem.
Res. 1993, 26, 593-598
2
Cation-p Interactions is Chemistry and Biology.
Dougherty, D. A. Science, 1996, 271, 163.
K
H2O
H2O K
18
3
Cation-p Interactions is Chemistry and Biology.
Dougherty, D. A. Science, 1996, 271, 163.
Ka 740
in water!
4
Cation-p Interactions is Chemistry and Biology.
5
Cation-p Interactions is Chemistry and Biology.
neurotransmitters important cations in biology
6
Cation-p Interactions is Chemistry and Biology.
neurotransmitters important cations in biology
7
Cation-p Interactions is Chemistry and Biology.
nicotinic acetylcholine receptor
8
Drugs that act on the brain. Serotonin and SSRIs.
O
O
H
O
H
O
N
H
2
O
H
O
H
N
H
N
H
tryptophan hydroxylase
2
2
hydroxytryptophan decarboxylase
N
N
N
H
H
H
serotonin
5-hydroxytryptophan
tryptophan
(5-hydroxytryptamine)
synapse
serotonin receptors
monoamine oxidase(MAO)
serotonin re-uptake site
9
Drugs that act on the brain. Serotonin and SSRIs.
O
O
H
O
H
O
N
H
2
O
H
O
H
N
H
N
H
2
2
N
N
N
H
H
H
Fluoxetine
10
Cation-p Interactions is Chemistry and Biology.
Chemistry Biology 2005, 12, 993-997
phenylalanine F
tyrosine Y
tryptophan W
neurotransmitters important cations in biology
11
Cation-p Interactions is Chemistry and Biology.
neurotransmitters important cations in biology
12
Cation-p Interactions is Chemistry and Biology.
neurotransmitters important cations in biology
13
Cation-p Interactions is Chemistry and Biology.
neurotransmitters important cations in biology
14
Cation-p Interactions is Chemistry and Biology.
squalene oxide
lanosterol