Title: Quelques bases exp
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2Introduction
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12Quelques bases expérimentales
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24Méthologies basées sur la RMN des ligands
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35NMR Automation
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40Méthologies basées sur la RMN des récepteurs
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49Interactions protéines-protéines, hydrodynamique
des récepteurs
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5215N1H Spin Relaxation of Poplar Prx-D
Biochemistry (2004) in the press
53Peroxiredoxin family has different types of
quaternary structures
Biochemistry (2004) in the press
54Spin Relaxation Analysis in Terms of
Rotation-Diffusion
RotDiff (Walker, 2004)
Inertia (X-ray model)
HydroNMR (De la Torres, 2000)
O. W.
55Homodimer type validation using HydroNMR
Biochemistry (2004) in the press
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57Recent and Future Technical Advances in NMR
- The sensitivity, which also improves at high and
very high fields, is gained by factor 2 to 3
using the cryo-probe technology - Basically biomolecular NMR will not require
anymore 500 or 200 ?l of 1 mM (35 mg/ml at 35
kDa!!) sample, but less than 100 ?M solutions. - Microsensors in NMR probes used in LC-NMR or
hyphenated technics, already require only 3
to 1,5 ?l samples.