Recovery of Biological Products 10

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Recovery of Biological Products 10
Welcome to Cancún
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Moctezuma and the gardner of paradise
Quetzalcóatl (Kulkulcán)
Moctezuma Aztec Emperor 1440 1469
50 flasks of chocolate/day
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Creative efforts

• Program excellence subjects and attendees
• Core subjects integrated process design
• Impact of genomics and proteomics
• Latest research and developments
• Opportunities for open discussion

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You are here!
Activity centre
Reef
Mangroves
Have fun!
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Lessons from the past

• 1968
• 150 tons 75 protein p.a.
• 5,000 kgs whey/hour

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Learning for the future

• Cell and tissue engineering
• In silico models
• DNA microarray devices
• Downstream processing
• moves to the front

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Conference Statistics - Subject Areas
Oral Workshop Poster Total Process 16 5 18 39 Va
lidation     7 7 Chromatography 7 5 26 38 EBA 1 1
12 14 Membrane Filtration 1 3   4 Membrane
Chromatography 1 3 4 Crystallization 2   1 3 Dept
h Filtration   1 1 2 Extraction 1 1   2 Refolding
    2 2 Foam Fractionation   1   1 Magnetic
Separations 1     1 Centrifuge     1 1 Centrifugal
Precipitation Chromatography     1 1 Electrophore
sis     1 1 Drum Vacuum Filter   1   1 Cryopreserv
ation     1 1 Genomics 3     3 Combinatorial 3    
3 Ligands 1   9 10 Transgenics 1   1 2 Cell and
Tissue 1     1 Analytical 1     1 Total
40 20 82 142
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Papers by product type
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What are we all doing?
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attendees
Australia Austria Belgium Canada Chile Cuba Denmar
k Finland France Germany Iceland Japan Korea New
Zealand Portugal Slovenia Sweden The
Netherlands UK USA
72
146
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3
3
Europe 31
Australasia 3
N. America 65
S. C. America 1
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attendees
New and repeat attendance
RX
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400 Applicants 228 Attendees 129 participants
from sponsors 144 Abstracts accepted
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Xcaret Thursday afternoon
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Recovery science

• ...... from the very beginnings of chemistry
  until our own time, methods of separating
  substances have occupied a key position in this
  science .... and even today some of chemistrys
  most important advances are linked to the
  invention of new methods for separating various
  substances.
• Arne Tiselius, 1952

Archer Martin Richard Synge
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Academic industry traditions

• Columbia University
• University - Göttingen
• General Electric Company
• Nobel Prize in chemistry 1932
• Mountaineering
• Skiing
• Flying

Irving Langmuir
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Alan Michaels
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Recovery of Biological Products

• First conference in 1981
• Initiated under the auspices of the Engineering
• Foundation
• Second conference established the Series
• Co-sponsored in 1994 by the ACS
• Since 1999 ACS - BIOT is the organizational
  sponsor

RECOVERY OF BIOLOGICAL PRODUCTS CONFERENCE
SERIES
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Conferences in the Series
When will the next conference be?????
RECOVERY OF BIOLOGICAL PRODUCTS CONFERENCE
SERIES
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Past chairs
Whos next .........????
RECOVERY OF BIOLOGICAL PRODUCTS CONFERENCE
SERIES
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Conference locations
Attendees
Where will the next meeting be????
RECOVERY OF BIOLOGICAL PRODUCTS CONFERENCE
SERIES
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Initial steps, refolding 1981 - 2001
Number
Number
Extraction
Expanded/Fluidized beds
Number
Number
Cell lysis/disruption
Refolding
RECOVERY OF BIOLOGICAL PRODUCTS CONFERENCE
SERIES
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Unit operations 1981 -2001
Number
Number
Membranes
Chromatography
Number
Number
Electro-separations
Membrane chromatography
RECOVERY OF BIOLOGICAL PRODUCTS CONFERENCE
SERIES
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Process modelling and control 1981 - 2001
Number
Number
Modelling, control, automation
Analytical/On-line monitoring
RECOVERY OF BIOLOGICAL PRODUCTS CONFERENCE
SERIES
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New chemistry 1981 - 2001
Number
Genetic solutions, tags Combinatorial chemistry
RECOVERY OF BIOLOGICAL PRODUCTS CONFERENCE
SERIES
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Transgenics, gene therapy 1981 - 2001
Number
Number
Transgenics
Gene therapy
RECOVERY OF BIOLOGICAL PRODUCTS CONFERENCE
SERIES
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1981 The inaugural year
Science and industry have come a long way to the
present, diversified array of expression and
production systems and from No approved
recombinant products in 1981 to 15 in 1991 to
around 100 approved products in 2001. Early
topics such as Recovery of low MW products such
as antibiotics, organic acids, and ethanol as
well as waste treatment have essentially disappear
ed from the Recovery series.
RECOVERY OF BIOLOGICAL PRODUCTS CONFERENCE
SERIES
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A decade later - 1992
RECOVERY OF BIOLOGICAL PRODUCTS CONFERENCE
SERIES
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The New Millennium
RECOVERY OF BIOLOGICAL PRODUCTS CONFERENCE
SERIES
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Sponsors
Genzyme Corporation Genzyme Transgenics
Corporation GlaxoSmithKline Immunex
Corporation Integrated Biosystems, Inc. Kendro
Laboratory Products, L.P. Life Technologies,
Inc. Lonza Biologics plc Merck Co., Inc. Merck
KGaA Millipore Corporation Millipore
Bioprocessing Neose Technologies Novo Nordisk
A/S Pall Biopharmaceuticals Pfizer Inc. ProMetic
BioSciences, Inc. Sachem, Inc. Sartorius
AG Sepragen Corporation Tosoh Corporation Tosoh
Corporation, GmbH Whatman International
Ltd. Wyeth-Lederle Vaccines
Abgenix, Inc. Amersham Pharmacia Biotech Amgen
Inc. Aventis Behring L.L.C. Aventis Pasteur Bayer
Corporation Berlex Laboratories, Inc. BIA
Separations d.o.o. Biogen, Inc. Bio-Rad
Laboratories Inc. BioReliance Corporation Boehring
er Ingelheim Pharma KG Corixa Corporation Dyax
Corporation Eli Lilly and Company Genencor
International, Inc. Genentech, Inc. Genetics
Institute, Inc. Geneworks, L.L.C.