Development of the Vertebrate Body Plan

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Development of the Vertebrate Body Plan

• Thomas A. Marino, Ph.D.
• Department of Anatomy and Cell Biology.

Temple University School of Medicine
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DEVELOPMENT OF THE VERTEBRATE BODY PLAN

• Early Development
• 1. Development of Ectoderm
• A. Neural Tube
• B. Surface Ectoderm
• 2. Development of Endoderm
• A. G.I. Tract
• B. Respiratory Tree
• C. Pharynx
• 3. Development of Mesoderm
• A. Paraxial
• B. Intermediate
• C. Lateral

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Summary of Week 2
Trophoblast
Cytotrophoblast
Syncytiotrophoblast
Embryonic Ectoderm
Embryonic Mesoderm
Embryonic Epiblast
Mesoderm
Extraembryonic mesoderm
Blastocyst
Primitive Streak
Notochordal Process
Epiblast
Notochord
Embryonic Endoderm
Amnioblasts
Inner Cell Mass
Extraembryonic endoderm
Yolk Sac Endoderm
Hypoblast
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Trilaminar Embryo
Ectoderm
mesoderm
Notochord
Endoderm
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Trilaminar Embryo
paraxial mesoderm
paraxial mesoderm
intermediate mesoderm
lateral mesoderm
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Ectoderm
Yolk Sac
Cut edge of Amnion
Primitive Node
Primitive Streak
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Ectoderm
Primitive Node
Epiblast
Primitive Streak
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Ectoderm
Notochord
Lack of BMP-4 Presence of Noggin Chordin Follista
tin WNT-4a FGF
Forebrain Midbrain Hindbrain Spinal cord
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Ectoderm
Notochord
Neural Plate
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Ectoderm
Notochord
Neural Plate
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Ectoderm
Oral Plate
Prechordal Plate
Notochord
Neural Plate
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Ectoderm
Neural Groove
Neural Plate
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Ectoderm
Neural Groove Neural Fold Somites
Day 20
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Ectoderm
Somites
Pericardial Bulge
Neural Tube
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Ectoderm
Cranial Neuropore
Pericardial Bulge
Somites
Caudal Neuropore
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UNSW Embryology
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Ectoderm

• The role of the cytoskeleton in the development
  of the neural tube
• Actin filaments

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Ectoderm

• The role of the cytoskeleton in the development
  of the neural tube
• Microtubules

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Development of the Neural Tube
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Development of the Neural Tube
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Development of the Neural Tube
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Development of the Neural Tube
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Development of the Neural Tube
Surface Ectoderm
Neural Crest Cells
Neural Tube
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Development of the Neural Tube
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Development of the Neural Tube
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Lateral Body Folding
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Lateral Body Folding
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Lateral Body Folding
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Lateral Body Folding
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Lateral Body Folding
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Lateral Body Folding
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Lateral Body Folding
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Lateral Body Folding
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• UNSW Embryology

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Lateral Body Folding
Paraxial mesoderm
Intemediate mesoderm
Surface ectoderm
Neural Tube
Amniotic Cavity
Body Cavity
Chorionic Cavity
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Surface Ectoderm
cranial and sensory ganglia and nerves, medulla
of adrenal gland, pigment cells, branchial arch
cartilages, head mesenchyme
epidermis, hir, nails, cutaneous and mammary
glands, anterior pituitary gland, enamel of
teeth, inner ear, and lens
Neural Crest
Neural Tube
central nervous system, retina, pineal
body, posterior pituitary