Sasai and De Robertis, 1994

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(No Transcript)
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Differential Subtractive Screen yields Chordin, a
BMP-4 antagonist (1994)
(Sasai and De Robertis, 1994)
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Functional Expression Cloning yields noggin, a
BMP-4 antagonist (1992)
Fractionate cDNA library cDNAs to RNAs


pool 1
pool 2
pool n
(inject RNAs)
(Smith and Harland, 1992)