Title: Voice Therapy: Following the Evidence Trail
1Voice Therapy Following the Evidence Trail
- Joseph C. Stemple, Ph.D.
- Lisa B. Thomas, M.A., Doctoral Candidate
2(No Transcript)
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4Voice Therapy Orientations
- Hygienic
- Symptomatic
- Physiologic
- Eclectic
5Hygienic Voice Therapy
- Discover the behavioral causes of the voice
disorder modify/eliminate of the causes to
improve the voice
- Organized and promoted by every text related to
voice disorders
- There is often a behavioral cause for a voice
disorder discover, modify/eliminate it and the
voice improves
6Symptomatic Voice Therapy
- Modification of deviant vocal symptoms such as
breathiness, inappropriate pitch, loudness, hard
glottal attacks, and so on
- Organized and promoted by Daniel Boone in his
text The Voice and Voice Therapy (1971)
- If the voice component is inappropriate, modify
that component with voice facilitating techniques
7Physiologic Voice Therapy
- Based on expanded knowledge of vocal function as
evaluated through objective voice assessment and
measurement
- Strives to improve the relationship or balance
among voice respiratory support, laryngeal muscle
strength, control and stamina, and and
supraglottic modification of the laryngeal tone
8Physiologic Voice Therapy
- Presented by Colton and Casper (1990) and
Stemple, Glaze, and Gerdeman (1993)
- Concentrates on the modification of the
underlying physiology of the voice producing
mechanisms respiration, phonation, resonance
9Eclectic Voice Therapy
- Combination of any and all of the previous
orientations to affect positive vocal change
- Voice pathologists should be aware of all
management approaches and use those which are
most effective not only for the patient, but for
the therapist as well
10What do we mean by following the evidence
trail?
- Many voice therapy interventions have become
standard practice with limited supporting data
- Clinical/medical/surgical practices have
out-paced the scientific evidence to support them
Why?
- Patients continue to show up at our doors
- We will continue to treat them with techniques
that APEAR to work
11Is Research Support Necessary in Clinical
Practice?
- How do we know that what we do in therapy
actually does what it is meant to do?
- How do we know that therapy success was the
technique and not the therapist?
- How many techniques and approaches do we use from
habit or because they seem to work?
- How many of us blindly follow the latest therapy
fad without the benefit of good data?
12Research Support cont
- Outcomes data should serve as the foundation of
clinical practice in voice pathology.
- Why?
- Concerns revolve around objective accountability
- Research funding has centered on the form and
quality of clinical outcome studies
- NIH Roadmap
13History of Outcomes Research in Voice
- Earliest reports 1940s
- Case Studies, Anecdotal reports
- 1980s and early 1990s
- Instrumentation advances
- Dramatic increase in number of outcome studies
- Primarily survey and retrospective studies. Some
group studies SS designs emerge.
- Lack of control and research rigor
14History of Outcomes Research in Voice
- Studies of the 1990s and 2000s
- Instrumentation advances
- Increased rigor in designs
- Lines of research developing
- Ex LSVT, Ramig et al. (1995)
15Decisions Regarding the Content of the Review
16Review Process Phase 1
- Medline, CINAHL, PsychINFO, ASHA journals (1980
present)
- Search terms voice therapy, efficacy, outcomes,
voice disorders
- Total citations 124
- 41 inappropriate population (SD, IPD)
- 46 not related to treatment efficacy, outcomes
- 7 non-English
- 30 studies for review
17Review Process Phase 2
- Historical search from pertinent readings 38
additional studies
- Review Process Phase 3
- Review, categorization, and rating of studies
- Butler and Darrah (2001) 5 level rating system
18Hygiene Therapy Evidence
- Direct treatment of voice appears superior to
vocal hygiene training
- Verdolini-Marston et al. (1995)
- Carding Horsley (1992)
- Carding et al (1999)
- Roy et al. (2001)
- Holmberg et al. (2001)
- Pasa et al. (2007) contradictory results (VH
increase in knowledge, decrease in self-reported
symptoms, however, no significant change in
direct measures of MPFR or MPT)
19Hygiene Evidence
Group hygiene training yields change in knowledge
but no change in behavior
- Knowledge
- Nilson and Schneiderman (1983)
- Aaron and Madison (1991)
- Pasa et al. (2007)
- Behavior
- Broaddus-Lawrence et al. (2000)
- Timmermans et al. (2004, 2005)
- Chan (1994)
20Hygiene Evidence
- Hydration reduces phonatory effort
- Verdolini et al. (1994)
- Verdolini-Marston et al. (1990, 1994)
- Solomon and DiMattia (2003)
- Fisher et al. (2001)
- Hydration increases vocal endurance
- Yiu and Chan (2003)
21HygieneConclusions Implications
- Few large scale studies support the therapeutic
benefit of general hygiene education
- Growing support for use of hydration
- Hygiene should be used only as an adjunct to
direct forms of treatment.
- Future work
- Monitor / quantify compliance
- Increase number of studies on disordered
populations
22Symptomatic Therapy Evidence
- Primarily case reports and anecdotal evidence
- Few group studies
- Majority of methods have Level IV and V evidence
- Many methods have no published evidence
23Symptomatic Evidence
- Evidence supports use of biofeedback
- EMG
- Prosek et al (1978) Stemple et al. (1980)
Andrews et al. (1986)
- Acoustic / Aerodyanamic
- Yamaguchi et al. (1986) Laukkanen et al. (2004)
- Laryngeal Function
- DAnontio (1987) Rattenbury et al. (2004)
24Symptomatic TherapyConclusions Implications
- One line of promising work - Biofeedback
- Future Directions
- Potential examination of theoretical bases of the
methods
- More rigorous research designs
25Physiologic Therapy Evidence
- Evidence
- Physiologic / theoretical evidence
- Clinical evidence
- Majority, well-controlled group studies
26Physiologic Clinical Evidence
- Lines of research for 4 methods
- Accent Method
- Smith Thyme (1976) Kotby et al. (1991) Fex et
al. (1994) Bassiouny (2001)
- Vocal Function Exercises
- Stemple et al. (1994) Sabol et al. (1995) Roy
et al. (2001), Gillivan-Murphy et al. (2006),
Bell et al. (2007)
27Physiologic Evidence
- Resonant Voice Therapy
- Verdolini-Marston et al. (1995) Chen et al.
(2003) Roy et al. (2003) Bell et al. (2007)
- Manual Laryngeal Musculoskeletal Reduction
Technique
- Roy and Leeper (1993) Roy et al. (1997) Van
Lierde et al. (2004)
28Physiologic TherapyConclusions and Implications
- Orientation came to forefront at time of efficacy
emphasis
- Evidence supports a shift from symptomatic Tx to
physiologic Tx
29Conclusions Implications
- Orientations
- Physiologic methods possess strongest support
- Efficacy of hygiene training inconclusive
- Lack of evidence for symptomatic therapy
- Future Directions / Questions
- Should symptomatic be examined or revised?
- Determine ways of examining hygiene more fully
- Consider / replicate model lines of research in
voice
30Does Science Support the Art of Voice Therapy?
- Historically an art form
- Shift to science base in 1990s 2000s.
- Instrumentation
- Societal focus on outcomes research
- Current Tx models have scientific support
31Full Review Published In
Thomas, L.B., Stemple, J.C. (2007). Voice
therapy Does science support the art?
Communicative Disorders Review, 1, 51-79.
32Designing the Vocal Hygiene Protocol
33Vocal Hygiene
- Evidence suggests
- VH does not stand alone as a treatment for voice
disorders
- Best used as a complement to other therapies
- May insulate patient from further voice
deterioration
34Vocal Hygiene
- May exert influence due to
- Elimination of poor vocal habits which
contributed to / perpetuated the disorder
- Lays the foundation for progress
- Maintaining the health of the vocal fold cover
- Hydration
- Reduction of acidic irritants or other irritants
of the mucosal cover
35Vocal Hygiene A Typical Protocol
- Vocal hygiene counseling involves
- identifying the abusive behaviors
- describing the physiologic effects of those
behaviors on the voice production mechanisms
- defining the specific occurrences
- modifying or eliminating the behavior
36Vocal Hygiene Components of a Standard Protocol
- Water intake considerations
- Manage intake of dehydrating substances
- Multiple forms beverages, OTC meds, prescription
meds, etc.
- Deal with chronic throat clearing / coughing
- Substitute behaviors
37Components of a Standard Protocol
- Strategic management of acoustic environment
- Diligent reflux management
- Symptomatic, Asymptomatic cases
- Vocal warm-ups as needed
38Vocal Hygiene Final Thoughts
- Vocal rest vs. Modified vocal rest
- Dictating vs. strategizing
- The KEY is patient education and patient
understanding
39Planning Physiologic Voice Therapy Protocols
40Research Support for Physiologic Voice Therapy
- What are physiologic voice therapies exactly?
- Good question (Probably just an academic term)
- Seems to relate to a therapy program involving
exercises or vocal maneuvers that attend to all
three subsystems of voice production at once,
respiration, phonation, and resonance
41Research Support for Physiologic Voice Therapy
cont
- These therapy programs are most often described
as physiologic approaches to voice therapy
- Accent Method
- Lee Silverman Voice Therapy
- Resonant Voice Therapy (LMRVT)
- Vocal Function Exercises
42Why is Treating the Physiology Critical?
- Diagnosis Symptoms, pattern of production,
etc.
- Example Nodules
- Example Paralysis
- Individualized responses to pathology
- Universal Goal Restore to normal physiology,
normal efficiency
- Treatment Need holistic method to restore normal
physiology
- Implication Some physiologic therapies
applicable across a broad range of pathologies
43Vocal Function Exercises
- A series of systematic voice manipulations,
similar in theory to physical therapy for the
vocal folds, designed to strengthen and
coordinate the laryngeal musculature, and to
improve the efficiency of the relationship among
airflow, vocal fold vibration, and supraglottic
treatment of phonation
44Vocal Function Exercises cont
- Long sustained tones
- Maximal pitch glides
- Efficient posturing of the voice producing
mechanism to permit maximum output with minimal
effort
45Genesis of VFE
- Bertram Briess
- Robert Stimpert
- Jan Barnes
46Vocal Function Exercises Primary Research Support
- Stemple J, Lee L, DAmico B, Pickup B (1994)
Efficacy of Vocal Function Exercises as a method
of improving voice production. J Voice, 8
271-278. - Double-blind, placebo-controlled study
- 35 females ages 21-25 with normal voice
- Pre and post-test acoustic, aerodynamic, and
videostroboscopic measures
- Performed VFE 2x each 2x per day for 4 weeks
47Stemple et al., 1994, cont
- Results
- Maximized use of phonation flow volume
- Decreased airflow rates
- Increased maximum phonation time
- Increased frequency range
- Improved the symmetry of vibration
- Average VFE phonation times increased with
plateau at 2 weeks
48Vocal Function Exercise Research Support cont
- Sabol J, Lee L, Stemple J (1995) The value of
Vocal Function Exercises in the practice regimen
of singers. J Voice, 9 27-36.
- 20 university graduate level opera majors ranging
in age from 26-39 years (men) and 21-43 years
(women)
- Pre and post-test acoustic, aerodynamic, and
videostroboscopic measures as well as perceptual
questionnaire
- Performed VFE 2x each 2x per day for 4 weeks
along with regular singing activities
49Sabol et al., 1995, cont
- Results
- Decreased airflow rates at both high and low
pitches (intensity and pitch were held steady for
pre and post-test)
- Increased MPT at all pitch levels
- Reported improvement in dynamic range control
- Average VFE times increased with plateau at 3
weeks
50Vocal Function Exercise Research Support cont
- Roy N, Gray S, Ebert M, Dove H, Corbin-Lewis K,
Stemple J (2001) An evaluation of the effects of
two treatments for teachers with voice disorders
A randomized clinical trial. JSHR, 44 286-296. - Assessed the functional effects of Vocal Hygiene
and VFE on 58 school teachers with self-reported
voice problems
- Subjects were randomly assigned to VFE, VH and
control groups
- Treatment phase lasted for 6 weeks
- Pre and post Voice Handicap Index (VHI) were
completed by all subjects
51Vocal Function Exercise Research Support cont
- Results
- Control group worse
- Vocal Hygiene group no change
- VFE group significant improvement
52Strategies for Physiologic Voice Therapy
- Vocal Function Exercises
- a series of systematic voice manipulations,
similar in theory to physical therapy for the
vocal folds, designed to strengthen and
coordinate the laryngeal musculature, and to
improve the efficiency of the relationship among
airflow, vocal fold vibration, and supraglottic
treatment of phonation
53Strategies for Physiologic Voice Therapy
- What is made of multiple cartilages, muscles, and
connective tissue and is a jointed system which
may become injured, weakened, or imbalanced in
its function?
54Strategies for Physiologic Voice Therapy
55Strategies for Physiologic Voice Therapy
- Rehabilitation for injuries of the knee
- rest to reduce edema
- appropriate supports, casts, bracings, and wraps
as needed
- ambulatory devices
- systematic exercise
- continuation of previous activities
56Strategies for Physiologic Voice Therapy
57Strategies for Physiologic Voice Therapy
- Rehabilitation for Injuries of the Larynx
- sometimes voice rest
- vocal hygiene counseling
- modify symptoms
- continuation of previous voicing activities
58Strategies for Physiologic Voice Therapy
59Direct Systematic Exercises
- Restrengthening and coordinating the laryngeal
musculature
- Enhancing the relationship of the three
subsystems of voice production
60Four Steps
- Warm up
- Stretching Exercise
- Contracting Exercise
- Adductory Strengthening Exercise
61Resonance
Phonation
Respiration
62Vocal Function Exercises
- (warm-up) Sustain the vowel /i/ for as long as
possible on the musical note (F)
- Goal __ sec (F above middle (C) for females
F below middle (C) for males)
63Vocal Function Exercises
- Posture
- Breathing
- Placement
- Onset
64Vocal Function Exercises
- (stretching) Glide from your lowest note to your
highest note on the word knoll, whoop, tongue
trill, lip trill
- Goal no voice breaks
ol
Lip Buzz
Pharynx
Lips
65Vocal Function Exercises
- (contracting) Glide from a comfortable high note
to your lowest note on the word knoll, boom,
tongue trill, lip trill
- Goal no voice breaks
66Vocal Function Exercises
- (power) Sustain the musical notes (C-D-E-F-G) for
as long as possible on the word old without the
/d/.
- Goal __ sec. (middle (C) females, octave below
middle (C) males
67Pitch Modifications
- G A B C D E F G A B C
- G A B C D E F G A B C
- G A B C D E F G A B C
68Vocal Function Exercises
- notes are matched to a pitch pipe, tape recorder,
key board, piano
- daily record is charted by the patient
- estimated time of completion 8-10 weeks
- some patients experience minor laryngeal aching
the first few days of exercise
69Vocal Function Exercises
- all exercises are done 2 x each, 2 x per day
- all exercises are done as softly as possible, but
engaged
- quality of tone is monitored for breaks,
wavering, and breathiness
- extreme care is taken to teach the production in
a forward tone focus without tension
- attention is paid to the glottal onset of the
tone to assure an easy onset without breathiness
- appropriate breathing technique is assured
70Explanation to the Patient
- Admit that it seems silly
- Compare it to workout program, physical therapy,
weight lifting, etc.
- Stress the necessity of systematic exercise
without breaks
- Explain that the times do not increase due to
increased lung capacity
71Advantages for the Patient
- Easily understood, reasonable model
- Systematic, permits plotting of progress
- Patient must attend to the voice at least 2 times
per day
- Involves doing something positive as opposed to
the dont dos
72Vocal Function Exercises
- Maintenance Schedule
- Full program 2 x each 2 x per day
- Full program 2 x each 1 x per day
- Full program 1 x each 1 x per day
- Exercise 4 2 x each 1 x per day
- Exercise 4 1 x each 1 x per day
- Exercise 4 1 x each 3 x per week
- Exercise 4 1 x each 1 x per week
Each taper involves approximately 1 week
73Future Research
- Clinical populations
- Measurement strategies
- Study the underlying physiologic principles of
the training modalities
74Resonant Voice Therapy
- Lessac (1965)
- The well-placed voice yields optimal functioning
of respiratory, phonatory, and resonance systems
- Titze (2003)
- RV maximum transfer of power through the vocal
tract from glottis to lips and ultimately to the
listener
- Proper energy conversion at the vocal folds
results in excellent propagation of sound --
vibrations of the glottal tone can extend into
the facial regions
75Resonant Voice Therapy
- RV produced with vocal folds barely separated
- Berry (2001)
- Glottic configuration observed in RV produces
maximum transfer of sound through vocal tract
- Implications Glottal configuration for RV is
most efficient use of the system
76Resonant Voice Therapy
- Voice production involving oral vibratory
sensations, usually on the anterior alveolar
ridge or higher in the face
- In the context of easy phonation
- Where resonant voice is a continuum of oral
sensations and easy phonation builds from basic
speech gestures through conversational speech
77Resonant Voice Therapy
- Training methodologies are experiential, focusing
on the processing of sensory information
- The training model assumes similar approaches for
voice restoration and enhancing the normal voice
(excellence training)
78Resonant Voice Therapy
- Fundamental perceptual target is focused, oral
vibratory sensations in the context of easy
phonation.
- The singular training focus (resonance) is
expected to affect multiple levels of physiology
(breathing and laryngeal).
- Large numbers of repetitions are used, in varying
speech contexts.
- Training is strongly goal (results) driven,
involving a dogged insistence upon the greatest
possible precision in the achievement of the
perceptual tasks.
79Resonant Voice TherapyPrimary Clinical Support
- 4 clinical studies
- Verdolini-Marston et al., 1995
- Roy et al., 2003
- Chen et al., 2003
80Basic RVT Training Maneuvers
- Stretches and Breathing Warm-Ups
- Shoulders
- Neck
- Jaw
- Floor of Mouth
- Lips
- Tongue
- Pharynx
81Basic Training Gesture for RT (This is Step 1
for all stages of RT)
- Holm-molm-molm-molm-molm..As a sigh
- Extreme forward focus is required with
appropriate breath support
- Make the connection from the abdominal muscles to
the lips
- Patient should feel very relaxed at the end of
this gesture
82RT Hierarchy Stage 1 All Voiced
- molm-molm-molm.. (sustained pitch) ____ note
- - vary the rate only
- - discover the vibrations experiment with
broad and narrow vibrations
- - eventually focus on the narrow vibration
like a narrow beam of light
- - increase the ease of production by reducing
the effort by 1/2 and 1/2 again
- - increase lift (as if pitch were
increasing)
83RT Hierarchy Stage 1 All Voiced
- 2. molm-molm-molm..
- slow-fast-slow
- soft-loud-soft on ____ note
- 3. molm-molm-molm.. as speech
- use non-linguistic phrase
- vary the rate, pitch, and loudness
- make the connection from the abdominal muscles to
the lips
84RT Hierarchy Stage 1 All Voiced
- 4. Chant the following voiced phrases on the
musical note ___
- Mary made me mad.
- My mother made marmalade.
- My merry mom made marmalade.
- My mom may marry Marv.
- My merry mom may marry Marv.
- Marv made my mother merry.
- 5. Over-inflect these phrases as speech
85RT Hierarchy STAGE 2 Voice-Voiceless
Contrasts
- Basic Training Gesture
- 1. mamapapa.. vary the rate on ___ note
- 2. mamapapa..
- slow-fast-slow
- soft-loud-soft on ___ note
- 3. mamapapa.. As speech
- use non-linguistic phrases
- vary the rate, pitch, and loudness
- make the connection from the abdominal muscles to
the lips
86RT Hierarchy STAGE 2 Voice-Voiceless Contrasts
- 4. Chant the following voiced/voiceless phrases
on the musical note ___
- Mom may put Paul on the moon.
- Mom told Tom to copy my manner.
- My manner made Pete and Paul mad.
- Mom may move Pollys movie to ten.
- My movie made Tim and Tom sad.
- 5. Over-inflect these phrases as speech
-
87RT Hierarchy STAGE 3 ANY PHRASE
- Basic Training Gesture
- Produce the following phrases in sequence as
follows
- First, chant the phrase on the note___, (no
breath)
- Then over-inflect it with extreme forward focus,
and
- Then finally repeat it as natural speech with a
forward focus.
- Note Each individual phrase should be produced
following this 3-step sequence before moving onto
the next phrase.
88RT Hierarchy STAGE 3 ANY PHRASE
- - All the girls were laughing.
- - Get there before they close.
- - Did you hear what she said?
- - Come in and close the door.
- - Are you going tonight?
- - Put everything away.
- - Come whenever you can.
- - We heard that yesterday.
- - The player broke his leg.
- - The children went swimming.
-
-
89RT Hierarchy Stage 4 Paragraph Reading
- read a paragraph with phrase markers
- separate each phrase only by the natural
inhalation of air
- exaggerate focus and then repeat with a more
normal speech/voice production
- repeat the above without phrase markers
90RT Hierarchy Stage 5 Controlled Conversation
- practice forward speech placement in
conversation
- do not permit glottal attacks, glottal fry, etc.
RT Hierarchy Stage 6 Environmental
Manipulations
simulate actual speaking environments
use tapes of background noise
go to noisy cafeteria
91RT Hierarchy Stage 7 Emotional Manipulations
- use materials and topics that increasingly engage
and challenge the patient
RT Home Exercises
The critical portion of each exercise for each
week is tape recorded as a home exercise example.
15-20 minute home sessions, two times per day w
ith minis as needed 1. Stretches 2. Basic RV
gesture 3. Selected level of hierarchy
92ConclusionsPhysiologic Voice Therapy
- Some methods applicable across broad range of
pathologies
- Goal of these methods is to restore normal
(efficient) laryngeal function
93Strategies for Psychogenic Voice Therapy
- The psychogenic voice disorders include
- conversion aphonia
- conversion dysphonia
- muscle tension dysphonia
- functional falsetto
- juvenile voice
- paradoxical vocal fold movement
94Strategies for Psychogenic Voice Therapy
- Management stages include
- 1. Medical evaluation
- -rule out organic pathology
- -confirms the psychogenic diagnosis
- 2. Diagnostic voice evaluation
- -develops the history
- -provides impression of patients personality
and shows how functions socially
- -gives physiologic rationale for voice problem
- -prepares the patient for vocal change
95Strategies for Psychogenic Voice Therapy
- 3. Direct manipulation of the voice
- -begins during the diagnostic evaluation
- -expected result is dramatic change toward
normal voice production
- 4. Counseling
- -determines the psychogenisis of the
disorder
- -determines the need for further professional
counseling
96Strategies for Psychogenic Voice Therapy
- Conversion aphonia
- non-speech phonation
- cough
- throat clear
- gargle
- falsetto voice technique
- laryngeal videoendoscopy feedback
- Conversion dysphonia
- same as aphonia
97Strategies for Psychogenic Voice Therapy
- Functional falsetto
- offer reasonable explanation
- hard glottal attack approach
- desensitization program
- Vocal Function Exercises/Forward Focus
98Treatment of Glottal Incompetence
- Goal Improved closure, more efficient use of the
system
- Methods Same as those used to enhance the system
with other behavioral conditions
- Working on basic physiologic level rather than
perceptual ideal
99Case Study Bilateral True Vocal Fold Bowing and
Sulcus
- 73 year old male
- Active lecturer
- Voice Quality
- Mild to mod dysphonia, weak raspy hoarseness
- Chief complaints
- Voice fatigue
- Laryngeal ache
- Progressive hoarseness
- Lack of clarity in voice
- Inability to project voice
100TREATMENT
- Vocal Function Exercises 2x ea 2x per day
- Airflow volume 3100 ml
- Goal 3100/80 40 sec
- 2-25-04 Baseline MPT 26.3 sec
- 3-4-04 35.2 sec
- 3-18-04 36.8 sec
- 4-1-04 42.2 sec
- 4-19-04 45.3 sec
101Therapy Results
- Normal voice quality
- No voice fatigue
- Ability to project voice
102Case Study Left True Vocal Fold Paralysis
- 70 year old female
- retired teacher/active volunteer
- May 21, 2004 Idiopathic LTVF Paralysis
- Voice Quality moderate dysphonia, high pitch,
weak breathy hoarseness
- Chief Complaints
- Hoarseness
- Inability to project
- Mild aspiration
103Treatment
- Vocal Function Exercises 2x ea 2x per day
- Airflow Volume 2000 ml / 80 25 sec
- 7-26-04 Baseline MPT 6.8 sec
- 8-2-04 12.0 sec
- 8-16-04 21.7 sec
- 9-16-04 24.2 sec
- 10-14-04 28.3 sec
104Therapy Results
- Mild dysphonia with occasional pitch breaks
- Ability to project
- No dysphagia
105So, what type of voice therapy should we be
practicing?
- Evidence-based
- Hygiene - present, may not be effective
- Symptomatic - limited, much more needed
- Physiologic - most studied, effective, needs to
be done with a wider population
- Cart before the horse research
- Understand that there are many therapy approaches
that are probably, might be, may be equally as
effective as those presented that have not been
systematically examined - Every patient is a potential subject. Lets
continue to explore
106(No Transcript)
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