Title: biochem
1BIOSYNTHESIS OF AMINOACIDS
2Amino acid name
- Alanine
- Arginine
- Asparagine
- Aspartic acid
- Cysteine
3- Glutamine
- Glutamic acid
- Glycine
- Histidine
- Isoleucine
4- Leucine
- Lysine
- Methionine
- Phenylalanine
- Proline
5- Serine
- Threonine
- Tryptophan
- Tyrosine
- Valine
6Overview
Overview
7Overview (cont)
8Metabolic Precursors Amino Acids a-ketoglutarate
Glutamate Glutamine Proline
Arginine 3-Phophoglycerate Serine Glyc
ine Cysteine
9- Metabolic Precursors Amino Acids
- Oxaloacetate Aspartate, Asparagine
- Methionine, Threonine,
- Lysine
- Pyruvate Alanine, Valine, Leucine
- Isoleucine
10- Metabolic Precursors Amino Acids
- Phosphoenolpyruvate Tryptophan
- and erythrose 4-phosphate Phenlyalanine
- Tyrosine
- Ribose 5-phophate Histidine
11a-Ketoglutarate Family
12a-Ketoglutamate to glutamate/glutamine
Glutamate NH4 ATP
Glutamine synthetase
Glutamine ADP Pi H
a-Ketoglutamate glutamine NADPH H
2 glutamate NADP
Glutamate synthase
13a-Ketoglutamate to glutamate/glutamine
Net Reaction a-Ketoglutarate NH4 NADPH
ATP L-glutamate NADP ADP Pi
14a-Ketoglutarate Family
15Synthesis of Proline
16Synthesis of Proline
17Synthesis of Arginine
18Synthesis of Arginine
193-Phosphoglycerate Family
20Synthesis of Serine and Glycine
21Synthesis of Cysteine
22Oxoloacetate Family
23Synthesis of Aspartate and Asparagine
Aspartate
Oxaloacetate
Transamination from glutamate
Amidation with Glutamine donating NH4
Asparagine
24Pyruvate Family
25Synthesis of Alanine
Alanine
Pyruvate
Transamination from glutamate
26Phosphoenolpyruvate and erythrose 4-phosphate
Family
27Synthesis of Chorismate
28Synthesis of Tryptophan
29Synthesis of Tyrosine and Phenylalanine
30Synthesis of Tyrosine and Phenylalanine (cont)
31Biosynthesis of Histidine
- When cursor points to a box further details will
be displayed in the status window below. If you
click on the box you will change to appropriate
reaction scheme or enzyme specification. - Continued from Histidine Biosynthesis (early
stages) - IUBMB 2001
32Possible Test Questions
- Provide the 6 metabolic precursors and the amino
acids which they lead to. - Duplicate the Amino Acid Synthesis Overview Flow
Chart. Expand the sections need to show the
synthesis of Glutamate, Glutamine, Proline,
Arginine, Serine, Cysteine, Glycine, and starting
from Chorismate Tryptophan, Tyrosine and
Phenylalanine. (40 points!!)
33 by RAMESH.NG M.TECH_BIOINFORMATICS