Master Class:

1
Master Class
Autonomic Nervous System
Robert Fisk, Ph.D., James Nemitz, Ph.D.,
John Nolte, Ph.D., Britt Sanford, M.D.

2
Human Nervous System

• Central Nervous System
• Peripheral Nervous System
• Autonomic Nervous System
• Somatic Nervous System

3
Nervous System
Central
Peripheral
Autonomic
Autonomic
Somatic
Somatic
4
ANS Target Tissues
4

• Cardiac Muscle
• Smooth Muscle
• Blood Vessels
• GI
• Respiratory
• Genitourinary
• Glands
• Endocrine
• Exocrine
• e.g., Sweat
• e.g., Mammary
• Adipose Tissue

5
Autonomic Nervous System
2

• Parasympathetic
• Cranio-Sacral Outflow
• (4) Cranial Nerves

Sympathetic Thoraco-Lumbar Outflow T1-L2
Parasympathetic Cranio-Sacral Outflow S2-S4
6
Parasympathetic Division
ANS

• Rest-and-Digest ? Systemic Homeostasis
• (2) sources Pre-Ganglionic Neurons
• Cranio-Sacral
• Brainstem
• (4) Cranial Nerves
• III, VII, IX, X
• Sacral Spinal Cord
• Pelvic Splanchnic Nerves (S2-S4)

7
Parasympathetic Division
(4) Cranial Nerves

• Oculomotor (III)
• Facial (VII)
• Glossopharyngeal (IX)
• Vagus (X)

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Parsympathetic Efferents
Cranial Nerves III, VII, IX

• Neuron 1 (Cell Body) in CNS
• Pre-Ganglionic
• Cell Process (Myelinated Axon) in PNS
• Neuron 2 in Autonomic Ganglion in PNS
• Post-Ganglionic
• Unmyelinated Axon in PNS
• Innervates Target Tissue (4)

9
Parasympathetic Cranial Nerves
CNs 3, 7, 9 ? Pre-ganglionic Fibers
1 (of 4) Cranial Ganglia
Post-ganglionic Fibers
Target Tissue Smooth
Muscle, Glands
10
Parasympathetic Cranial Nerves
Oculomotor (III) ? Ciliary Ganglion
Facial (VII) ? Pterygopalatine G.
Facial (VII) ? Submandibular G.
Glossopharyngeal (XI) ? Otic G.
Vagus (X) Ø Cranial Ganglion
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Parasympa-thetic Division ANS Motor
CN III
CN VII
CN IX
Vagus
12
ANS Cranial Parasympathetics CN III - Oculomotor
n.
Edinger-Westphal n.
Superior Orbital Fissure
Pupillary Sphincter m.
Ciliary Ganglion
Ciliary m.
13
ANS Cranial Parasympathetics CN VII - Facial n.
Superior Salivatory Nucleus Intermediate Nerve
Greater Petrosal Nerve
Pterygopalatine Ganglion
Lacrimal Gland
14
ANS Cranial Parasympathetics CN VII - Facial n.
Superior Salivatory Nucleus Intermediate Nerve
Chorda Tympani
Inferior Alveolar n.
Submandibular Gland
Submandibular Ganglion
Sublingual Gland
15
ANS Cranial Parasympathetics CN IX - Glossophary
ngeal n
Inferior Salivatory Nucleus
Tympanic N. Plexus
Lesser Petrosal Nerve
Otic Ganglion
Parotid Gland