Chemicals

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The Sanmar Group
ProCitius is a part of one of Indias most
respected business groups
Chemicals
Shipping
Speciality Chemicals
Engineering
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Organisation of businesses at Sanmar Speciality
Chemicals
Location Alathur (near Chennai)
Location Berikai (near Bangalore)
Dadra (near Mumbai)
Location Chennai
Location Bangalore
www.procitius.com
www.bangaloregenei.com
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Mission
To provide research services that help our
customers develop products speedily and
efficiently
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Models

• Custom Synthesis Laboratory
• Custom Synthesis Pilot
• Process Research

FTE / Deliverable based contracts
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Partnering in drug development
Manuf. under cGMP
Custom Synthesis
PRE- CLINICAL
DRUG DISCOVERY
CLINICAL TRIALS
DRUG LAUNCH COMM.
By ProCitius
Contract Research
Process Dev.
By customer
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Medicinal Chemistry Capabilities

• Support for
• - Lead generation
• Lead optimization
• Synthesis of reference compounds
• Starting materials
• Intermediates / Building blocks
• Preparation of compound libraries

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Integrated drug design and chemical library
synthesis

• Provide a comprehensive and one-stop discovery
  solution spanning
• customized and target-directed design,
• selection,
• synthesis
• of novel chemical entities.
• Our partners Strand Genomics (www.strandgenomics.
  com)

• Services offered
• Library design Pharmacoffold approach
• Annotations in silico technologies truPK and
  truTox
• Library characterization and synthesis - NMR and
  LC-MS purity gt90
• Resynthesis and analoguing services
• Scale-up of synthesis to provide quantities up to
  Kg (including cGMP material)   
• Synthesis of reference compounds, fully
  characterized to meet GLP requirements

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Under Order
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Process research

• Scale-up of established processes
• Process optimisation
• Identification of alternate viable synthetic
  methods
• Scale up synthesis of gram/ kilogram quantities
  of building blocks
• Manufacture of intermediates

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Reaction capabilities

• Alkylations HMDA-Na, RLi, Metal Hydrides
• Acylation
• Amidation EDCI, DCC, CDI
• Aromatic Amination - LDA
• Aromatisation Dehydrogenation
• Chiral alkylation - using Evans agent (Use of
  chiral auxiliaries Oxazolidinone)
• Condensation 1,3-Diketones Esters
• Cyclo-condensation Several Heterocycles
• Dihydroxylation Osmium tetroxide
• Formylations
• Grignard reactions
• Halogenation
• Heck Arylation

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Reaction capabilities .. 2

• Hydrogenation Hydrogenolysis
• Metallation MeLi / n-BuLi / s-BuLi / t-BuLi /
  LDA
• Mitsunobu coupling
• Oxidation Jones, Moffat, KMnO4, NaIO4, Nitric
  acid
• Oximation
• Reductions Catalytic, Metal hydrides, High
  pressure, Metal catalysed, Birch reductions,
  Diborane, LAH, DIBAL-H, Catalytic, NaCNBH3
• Suzuki Coupling
• Asymmetric synthesis
• Enzymatic resolution

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Key Profiles
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Key Profiles .. 2
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Kilo Lab

• All glass reaction vessels (20 L to 200 L)
• Operating temperature 70 to 250 C
• 20 L distillation assemblies
• Turbine agitator
• Operating pressure atmospheric to 2 mm Hg

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Pilot Plant
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Scale-up facilities

• Salient Features
• Secondary cooling system (Methanol cardice)
  temperatures of 78 C can be reached
• Agitators coupled to speed variators
• Flexible and multi-purpose
• Seamless transfer of technology scale-up
• Water system Two pass RO EDI
• Documentation meets cGMP requirements

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Analytical - in-house
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Library

• Hard copies of chemical abstracts from 1907
  1991
• Access STN database
• Access to SCI-FINDER
• Most essential reference books available for
  immediate reference
• Essential journals available J. Org. Chem., J.
  Med. Chem., OPRD

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Data Management

• Software
• Flow charts MS Visio or Micrografx
• Chemistry - Chemdraw
• Project management MS Projects 2002
• Communications Lotus Notes
• Data Management
• Access controlled
• On server with backup at a different location
• Thin / Terminal Client concepts
• Secured
• Records
• Currently Hard copies
• e-notebook capable (Cambridgesoft Chemdraw)

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Project Turnaround

• ProCitius is an Export Oriented Unit (EOU) which
  means that import of materials are duty free and
  take minimal time
• Typical time for procuring of laboratory grade
  reagents is 5 to 10 working days
• Working arrangements with Aldrich and Lancaster
  for direct / speedy processing of orders and
  supply of chemicals
• Projects are completed to the expectation of
  customers quality, quantity and time-line
  requirements

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Project Reporting

• Gantt Chart provided at start of project
• Weekly reports provided every Friday on status
• Teleconferences Video-conferencing on periodic
  basis
• Project coordinator accessible round the clock
• Detailed report submitted within two weeks on
  completion of project covering
• - Project summary
• - Experimental details
• Synthetic Scheme, Raw Materials, Critical
  Issues, Stepwise Process
• Description, Modifications carried
  out to documented processes,
• Literature References, Copies of
  Laboratory notebook
• - Analytical methods and data

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SHE

• Safety
• PPE is a culture
• Safety Assurance Teams
• Safety Audits
• HAZOP studies
• Health
• Pre-employment medical clearance
• Periodic Health Checks
• Area monitoring
• Environment
• Waste segregation
• Waste minimization
• Full-fledged effluent treatment
• Complaince to local laws

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Key Attributes that make us Different

• Quality of products and services
• Zero defects
• Timely, reliable reports and feedbacks
• Innovation
• Ownership of IPRs
• Successes through novelty in Chemistry
• Employee talent
• High ratio of Ph.Ds and Postdocs
• Good academic background

• Quality of Management
• Transparent
• Rational and logic based
• Use of corporate assets
• ERP (SAP) Communication networks
• HR Practices
• Financial soundness
• Effective working capital management
• Corpus support from parent

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The Sanmar Group
The Sanmar vision
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The Sanmar Group
Joint Venture partners
7. Smith Meters Inc., USA (Subsidiary of
FMC Technologies Inc.) 8. Tyco International
Ltd., USA 9. Vishay Transducers Ltd., USA 10.
Weigh-Tronix Corporation, USA 11. Xomox
Corporation, USA (Subsidiary of Crane
Co.)
1. AMP, Australia 2. Automatic Switch Co., USA
(Subsidiary of Emerson) 3. BSB Safety Systems
Inc., USA 4. Cabot Corporation, USA 5. Fisher
Controls International Inc., USA (Subsidiary
of Emerson) 6. Flowserve Corporation, USA
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Why choose ProCitius ?

• Complement and not compete
• Talent pool infrastructural excellence
• Groups pedigree and ethics
• We respect and do not violate IPRs
• Project management
• Good track record

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Fast forward drug development
Thank you