vanillin

1
vanillin

• Presented by,
• G.Hemalatha
• K.Chandar
• K.Nagaraju
• P.Kamaldas
• V.Kalpana

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introduction

• Vanillin is a herbal drug obtained from the dried
  pods of Vanilla planifolia
• synonymvanilla beans, vanilla pods
• Family Orchidaceae

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Chemical structure

• Chemically vanillin is,
• 4-hydroxy 3-methoxy benzaldehyde.

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Aim of the work

• To synthesise the semisynthetic derivatives of
  vanillin which are used in our daily biological
  activities.

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Objectives of the work

• To optimize the biological activity of the
  compounds selected in the study.
• The compounds selected for the study are volatile
  in nature, formation of non volatile derivative
  with a better activity avoids the wastage through
  vaporization and also increases the potency.
• The compounds to be synthesized in this study are
  very simple derivatives and follow one or two
  step reactions, thus there is very less chance
  for the degradation of the starting compound.
• The compounds synthesized in this study will be
  subjected for TLC, physical and spectral analysis
  in order to identify purity, and to interpret the
  structure of the derivatives synthesized.

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plan of the work

• Based on this concept the present work was
  designed to synthesize semisynthetic derivatives
  of some commonly used phytoconstituents. In the
  present study semisynthetic derivatives of
  vanilla are synthesized. These derivatives are
  chosen due to their wide pharmacological activity
  and are used in our day to day life.

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• Experimental work
• procedure
• Take about 1 gm of hydrazine sulphate, 0.8 gm of
  sodium acetate in little quantity of distilled
  water and shaken well, added 2 gm of vanillin and
  shaken well till it becomes clear solution, if
  necessary add ethanol to dissolve the contents.

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• The thoroughly dried substance is to be subjected
  for analytical work
• In this experiment vanillin is treated with
  semicarbazide in the presence of sodium acetate.
• The resulted product is Hydrazine methylidene
  vanillin

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• The entire mixture warmed on water bath
  continuously for about 1 hour under reflux and
  allowed to cool to get the compound hydrazine di
  methyl vanillin, which is filtered and subjected
  for recrystallization with suitable solvent like
  alcohol.

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• uses
• The uses of the newly generated product are
• Analgesic
• Antibacterial
• Anti helmenthic

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Uses of vanillin

• Flavouring agent
• Perfumary
• Masking agent

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conclusion

• The literature survey reveals that some
  activities like Antibacterial, Antioxidant
  analgesic activities etc which are found weak,
  to increase its biological activity,a
  modification of functional groups in the
  structure/ modification of structure, may
  increase their pharmacological actions.

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bibliography

• Satyajit D Sarker, Lutfun Nahar, Chemistry For
  Pharmacy students General , Organic and natural
  Product Chemistry, Nat prod chem, John Wiley
  Sons Ltd, chapter 6,pg no.283-289, 2004.
• Dr. C. K. Kokate, A. P. Purohit, S. B. Gokhale,
  Pharmacognosy,Nirali prakashan Pune, thirty
  eighth edition, p.no1-6,2007
• Newman DJ, Cragg GM. Natural products as sources
  of new drugs over the last 25 years J Nat Prod,
  70, 461-477 (2007).
• Dan Bensky, Steven Clavey, Erich Stoger, and
  Andrew Gamble Chinese Herbal Medicine Materia
  Medica Third Edition 2004.

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