Oesophageal Cancer

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Oesophageal Cancer

• Aaron Hui

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• Introduction

• 2 Main types (squamous and adenocarcinoma)
• Incidence of adenocarcinoma is rising
• 3-4 / 100000 Western society
• Poor Prognosis

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Pathophysiology

• Chronic Mucosal irritation
• Genetic factors
• Environmental factors

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Barretts Eosophagus
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Clinical presentation

• -Dysphagia
• -Weight loss
• -Routine screening for Barretts
• -Hoarseness
• Distant metastasis
• Paraneoplastic syndrome

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Diagnosis

• Barium Studies
• Gastroscopy
• CT, PET
• EUS

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Surgical Treatment
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Gastric Cancer

• Aaron Hui

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Introduction

• Majority adenocarcinoma
• 50 of people have locally advanced disease at
  time of presentation
• 2 main types
• A proven infectious agent

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Pathophysiology

• Intestinal-type (well-differentiated)
• Pre neoplastic cascade
• 1. Non atrophic gastritis ? 2. Atrophic gastritis
  ? 3. Intestinal Metaplasia ? 4. Dysplasia ? 5.
  Invasive Carcinoma
• Diffuse type (poorly differentiated)
• - E-cadherin

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Diagnosis

• Barium studies
• Gastroscopy
• High resolution Helical Abdo CT

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Surgical Treatment