Manitoba’s Health Sciences

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BIOAWARE 1.5
Opportunity Innovation
Life Sciences in Manitoba
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Biography

• David Blicq
• Instructor - Chem. Biosciences RRC
• ISO Research Manager (Biodiagnostics)
• Researcher NSERC (UM)
• Consultant (strategic development)
• Multimedia learning resource design

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Agenda

• Employment numbers (life sciences)
• Health sector activities
• Types of work environments
• Research
• Production
• Quality Assurance / Control
• Health companies
• Health research

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Employment figures

• Life sciences sector 4,200 employees
• 41 companies (17 agri-food, 22 biomedical, 2
  environmental)
• 2300 are in 5 companies (Cangene, Biovail,
  Apotex, Monsanto VitaHealth)
• 30 research and development establishments employ
  1900 people
• There are 23 service firms that support the life
  sciences industries.

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Life Sciences Activities

• Pharmaceutical research production
• Infectious diseases
• Cardiovascular diseases
• Cancer / oncology / child health
• Non-invasive biodiagnostics
• Molecular biology, Mapping Gene Cloning
• Proteomics Bioinformatics

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Life Sciences Activities

• Bacterial Fermentation Metabolic Engineering
• Marker-assisted Gene Selection
• Proteomics
• Level 3 4 Bio-containment
• Biological Mass Spectrometry
• Role of nutrition in health

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Work Environment

• Three Main Areas
• RD Research and Development
• Production
• QA/QC Quality Assurance / Quality Control

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Research Team

• Works in a laboratory environment
• Find product / idea with value
• Characterize composition, potency, etc.
• Establish product specifications
• Develop analytical / manufacture methods
• Microbiological considerations
• Raw materials equipment specifications

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Research Job Titles

• Scientist
• Research Scientist
• Research Associate
• Research Technician
• Laboratory Technician
• Laboratory Scientist
• Media Preparation Technician

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Production Team

• Works in a Production (GMP) facility
• Makes the product biochemical, etc.
• Work with large volumes / equipment
• Routine operation, cleaning, calibration and
  maintenance of equipment
• Monitoring and control
• Follow SOP (standard operating procedure)
• Complete forms, labels, log-books (GMP)

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Production Job Titles

• Manufacturing Operator
• Manufacturing Technician
• Manufacturing Supervisor
• Production Technician
• Pilot Plant Operator
• Pilot Plant Technician

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QA / QC Team

• Works in office, lab and inspects facility
• Monitor equipment, facilities, personnel, product
• Review all production procedures
• Ensures document / record accuracy
• Test samples of product and raw materials
• Compare results to established standards
• Approve product release

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QC / QA Job Titles

• Quality Assurance Technician
• Quality Control Technician
• Assay Analyst
• Documentation Specialist
• Compliance Specialist
• Internal Auditor

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Work Environments

• Life Sciences Regulated Industries
• Strict controls for materials affecting human
  health
• Facilities have to meet exact requirements
• Methods have to be inspected and approved (Health
  Canada, FDA, etc.)
• People have to trained, tested and authorized to
  participate

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Work Environments

• Academic / Gov. Research
• University or Research Organization lab
• Investigate fundamental problems in biology /
  chemistry (etc.)
• Product is knowledge or information
• Research may have to be validated following GLP /
  ISO
• Require degree(s)

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Work Environments

• RD Laboratories in Industry
• Work in-house laboratory (small / large)
• Investigate with intent of a commercial product,
  conduct scale-up / pilot plant
• Focused, aggressive, highly effective
• Work conducting following recognized protocols
  ISO, GLP, etc.
• Require diploma / degree

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Work Environments

• Production Facilities
• Warehouse-scale manufacturing operations
• May be highly sanitary
• May be noisy and damp
• Can be simple job or highly complex
• Entry from college / high school

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Work Environments

• Testing Labs (QA, Microbiol, Clinical)
• Independent or governmental labs
• Perform tests on samples / devices
• May be highly routine
• May be occasionally variable
• Facility is often certified GLP / ISO
• Diploma / degree required

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Health Companies
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Health Companies

• Apotex Fermentation Inc.
• AFI uses fermentation-based technologies for the
  production of Active Pharmaceutical Ingredients
  (APIs).
• The Winnipeg facility is the largest
  fermentation-based GMP facility in Canada.

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Health Companies

• Biovail Corporation
• Formulation, clinical testing, manufacturing of
  pharmaceutical products.
• Biovail has operations in the US and Canada, and
  a research facility in Ireland.

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Health Companies

• Medicure Inc.
• Development of drugs for cardiovascular diseases
  and stroke.
• The company's lead product, MC-1, reduces
  ischemic injury caused by restrictions in blood
  flow.

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Health Companies

• Viventia Biotech Inc
• Innovative therapeutics based upon the human
  immune response to cancer.
• Develops monoclonal antibodies to fight multiple
  forms of cancer.

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Manitoba Research
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Infectious Diseases

• Canadian Science Centre for Human and Animal
  Health (CSCHAH)
• A leading research location for infectious
  disease
• Study human pathogens zoonotic diseases, prion
  diseases, influenza virus, enterics, STDs,
  hepatitis, tuberculosis, genomics, antimicrobial
  resistance, foreign animal diseases.

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Infectious Diseases

• Canadian Science Centre for Human and Animal
  Health
• The laboratory is the first and only global
  centre with level-4 bio-containment capabilities
  for the study of both human and animal diseases.

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Cardiovascular

• Institute of Cardiovascular Sciences
• Involved in drug discoveries for the treatment of
  heart failure, ischemic heart disease, and
  diabetes.
• Located at the St. Boniface General Hospital
  Research Centre

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Nutrimedicine

• National Centre for Agri-food Research in
  Medicine
• Within St. Boniface General Hospital Research
  Centre
• Studies health-related benefits of natural health
  products
• Evaluates health benefits, medical side effects,
  athletic performance through research and
  clinical trials.

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Clinical Trials

• I.H. Asper Clinical Research Institute
• Links basic medical research programs at the St.
  Boniface General Hospital Research Centre with
  patient care.
• Conducts Phase I and Phase II clinical trials on
  cutting edge pharmaceuticals for heart disease
  stroke.

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Medical Diagnostics

• Institute for Biodiagnostics (IBD)
• The National Research Council's IBD investigates
  instrumentation and methods for noninvasive
  diagnosis of serious health conditions (cancer,
  arthritis, heart disease, neurological
  conditions, and osteoporosis).
• Has the largest concentration of MRIs and NMRs
  for RD purposes in Canada.

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Child Health

• Manitoba Institute of Child Health
• Dedicated to pediatric research
• Has expertise in developmental pharmacology,
  respirology, genetics, and toxicology.

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Oncology

• CancerCare Manitoba
• A key RD facility (HSC) involved with the
  prevention, care, and research of cancer
• Recently constructed a 3 million breast cancer
  research facility (HSC)
• Also involved with Radiation Protection
  consultations and measurement services.

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Oncology

• Manitoba Institute of Cell Biology
• Studies the molecular origins of cancer and the
  role of signal transduction pathways in
  regulating cell proliferation.
• Also involved in developing markers of risk of
  developing invasive breast cancer

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Oncology

• Genomic Centre for Cancer Research and Diagnosis
  (GCCRD)
• Conducts research in genomic instability and
  mechanisms of neoplasia (formation of new
  tissue).
• GCCRD is part of the Manitoba Institute of Cell
  Biology (MICB), CancerCare Manitoba, and the
  University of Manitoba.

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Oncology

• Mammalian Functional Genomics Centre
• Creates diverse human disease models in mice, for
  rapid assessment of gene function.
• Created a library of mouse embryonic stem cells,
  each with a defined mutation in a cellular gene
  to help disease modeling

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Proteomics

• Manitoba Centre for Proteomics
• Analyzes human inflammatory diseases using
  proteomic approaches and identifies biomarkers
  for these diseases.
• The Centre is partnered with Applied Biosystems,
  Ciphergen Biosystems, and Chemicon International
  Corp.

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Proteomics

• Biomedical Proteomics Program, University of
  Manitoba
• The Biomedical Proteomics Program seeks to
  connect basic biological, agricultural and
  biomedical scientists with those scientists
  developing instrumentation and analytical
  software.

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• 32,000 students, 110-plus programs
• Applied Biopharmaceutical Processing
• Applied Biology
• Applied Chemistry
• Applied Pharmaceutics
•  Chemical and Biosciences Tech Co-op
• Environmental Protection Technology
• Medical Laboratory Sciences
• Medical Radiologic Technology
• MRI and Spectroscopy
• QA/QC in Pharmaceutical Industry

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Chemical and Biosciences Technology

• 2-year applied program at RRC
• Features
• Co-op job placement
• Exceptional laboratory training
• Provides skills employers want
• Enormous range of grad opportunities
• Joint 4-year degree program with UW

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Additional Resources

• Bioscience Websites - David Blicq / RRC
• Science Job postings
• Manitoba Bioscience news
• Course summaries and lab manuals
• Resumé and Cover letters
• On-line courses (viewable content)

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Additional Resources

• Other Content
• Study skills for science
• Employer-requested skill-sets
• Interview tips
• Lab documentation GLP / ISO
• Student pages

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BIOAWARE 1.5
Opportunity Innovation