Law of Bergonie’ and Tribondeau

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Law of Bergonie and Tribondeau
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Law of Bergonie and Tribondeau

• It was developed in 1906 by two French
  radiobiologist, Bergonie and Tribondeau
• It offers a prediction about the relative
  sensitivity of two different types of cells or
  tissues to radiation

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Law of Bergonie and Tribondeau

• It states that the radiosensitivity of cell is
  directly proportional to their reproductive
  activity and inversely proportional to their
  degree of differentiation.
• Cells most active in reproducing themselves and
  cells not fully mature will be most harmed by
  radiation.
• The more mature and specialized in performing
  functions as cell is, the less sensitive it is to
  radiation.

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More radiosensitive cells

• Cells that have a high division rate
• Cells that have a high metabolic rate
• Cells that are of a non-specialized type
• Cells that are well nourished

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Sensitivity Cell Cycle Phase

• Cells are most sensitive to radiation during
  mitosis (M phase) and RNA synthesis (G2 phase)
• Less sensitive during the preparatory period for
  DNA synthesis (G1 phase)
• Least sensitive during DNA synthesis (S phase)
• During mitosis (M), the metaphase is the most
  sensitive

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Radioresistant cells

• Bone
• Liver
• Kidney
• Cartilage
• Muscle
• Nervous tissue

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Radiosensitive cells

• Germinal cells
• Lymphoid tissues
• basal cells
• Hematopoietic tissues
• Epithelium of the GI tract

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Gonads are very radiosensitive

• Females
• Temporally sterility 1.5 Gy (150 rad)
• Permanent sterility 5 Gy (500 rad)
• Males
• Temporally sterility 2.5 Gy (250 rad)
• Permanent sterility 6 Gy (600 rad)

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Pregnancy and minors

• Children could be expected to be more
  radiosensitive than adults
• fetuses more radiosensitive than children and
  embryos even more in the first weeks of pregnancy
  when organs are forming

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Radiosensitivity of various cell types

• Radiosensitivity Cell type
• Low nerve cell
• muscle cells
• Intermediate osteoblast,endothelial
• cells,fibroblast,sp
  ermatids
• spermatogonia,
• lymphocytes, stem
  cells,
• High intestinal mucosa
  cells and
• erythroblast

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Questions

• The law of Bergonie and tribondeau states that
  the radiosensitivity of cell is directly
  proportional to their reproductive activity and
  inversely proportional to their degree of
  differentiation.
• - True
• 2. Those cells with a low metabolic rate are more
  radiosensitive.
• - False
• 3. Cells are more sensitive during meiosis phase.
• - False
• 4. Gonads are very radiosensitive cells
• -True
• 4. List four of the radioresistant cells.
• -bone, liver, kidneys, muscles