to

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Welcome to Sapala Organics Private Limited
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Sapala Organics Pvt. Ltd. Offering Expertise
in Organic Synthesis for Cost-Effective
Research and Production, since 2007 Quality
Deliverables with Speed
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Content

• Introduction
• Business Model
• Capabilities and Expertise
• Chemistry Services offering
• Advantage Sapala

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Introduction
Founders and Promoters Technical leaders from
industries and academia across the globe
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Mission and Vision
Vision To be a Respected Contract Research
Organisation (CRO) contributing to the society
Mission To be an organization skilled in
organic synthesis and a partner of choice for
diverse customers
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Business Models

• Fee for services
• Predefined Deliverables.
• Literature precedent for the preparation.
• Mutually agreeable timelines.
• Agreed cost (Resources Raw Material Cost)
• Full Time Equivalents (FTEs) Services
• Dedicated resources and laboratory
  infrastructure at Sapala
• Flexibility of work plans (WPs) and
  deliverables to client.
• Client can change priority of WPs as per
  internal development.
• Dedicated Project Manager One point contact
  at Sapala.
• Agreed FTE cost per annum inclusive of
  solvents, routine chemicals and disposable
• items for daily operations ( upto 10 g
  level).
• Special reagents specific for the project
  charged separately.

Flexible options Client may choose any thats
suitable.
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Team Sapala Staff Break Up
Technical Group
70
Support Group
55
125
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Chemistry Capabilities

• Synthetic and Medicinal Chemistry Support
• Focused libraries for supporting Hit to Lead
  campaign
• Drug standards and reference compounds with
  high purity
• Synthesis of building blocks and scaffolds
  enabling IP positioning
• Supply of hetero cyclic and natural product
  like scaffolds
• Synthesis of structurally attractive reagents
  and intermediates for med-chem
• support

• Material Chemistry Support
• Synthesis of Dyes for photo-functional
  applications.
• Synthesis of organic compounds for their
  application as nano tubes
• and electro / photochemical switches.

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Chemistry Capabilities

• Process Research and Scale up
• Route scouting.
• Optimization of reaction and unit processes.
• Optimization of processes for scale up from gm
  to Kg.
• Run single campaign based on Tech Pack (quick
  and dirty).

• Analytical Chemistry
• Analytical Method development and Validation.
• Spectroscopic analysis.
• Purification of high value material to achieve
  purity levels gt 99.5.

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Proven Experience

• Library synthesis
• Intermediates for drug candidates
• Reference compounds and Pharmaceutical
  Standards
• Drug metabolites, or degradation products
• Fluoro-, Alkylated-, carbohydrate synthesis
• Nucleoside chemistry, including synthesis of
  phosphoamidate
• Preparation of boronate reagents not described
  in literatures
• Bio-Organic transformations
• Multi step synthesis on large scale (15 steps
  100 gm delivery)

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Instrumentation

• FT NMR spectra for multi-nuclei (1H, 13C, 19F,
  31P)
• 2D NMR Experiments (COSY, HETCOR, HMQC, NOESY)
• HPLC-1 No (Agilent)
• HPLC 2 Nos (Jasco) 1 No Prep HPLC (Jasco)
• LC/MS 1 No (Shimadzu)
• FTIR (JASCO)
• Gas Chromatography analysis
• Specific Optical Rotation
• Medium Pressure Flash Column Chromatography
  (Grace-Davison)
• UV Spectrophotometer ( Jasco )
• Lyophilizer ( Labconco )

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Infrastructure

• Synthesis Laboratory
• Modular Laboratories with standard equipments
  and instruments
• Fume hoods
• Walk in fume hoods
• Rotary evaporators
• Prep HPLC purification system
• Flash chromatographic purification
• Humidity controlled facility
• Reaction performance temp range -78 to 200 C
• Analytical instruments (NMR, HPLC, LCMS-MS and
  GC).

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Good Practices

• Standard guidelines for safety and lab work.
• Regular audit and correct deviations from
  prescribed standards as per SOP.
• Strict compliance to Environment, Health and
  Safety.
• Safety committee representing all laboratory
  unit monitors compliance.
• Regular audits by internal representatives and
  external experts.
• Awareness programs and Training on various
  laboratory safety aspects conducted
• routinely.
• Documentation of all unsafe incidents and
  learning from the same shared with all
• employees.
• Personal Protective Equipment with high safety
  standards are provided to all scientists.
• Hospitalization and accident insurance
  covering.

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Project Management

• Dedicated Project Manager
• One point contact - Qualified Scientist (Ph D
  with Experience)
• Proactive Communication Daily / Weekly
• Responsible for all execution of scientific
  and technical guidelines
• Problem solving and knowledge input.
• Controls access to tech pack by team (need to
  know basis).
• Receptive to change of work plan priority as
  per the clients need.
• Weekly update / bi weekly report -
  teleconference.
• Quarterly evaluation of the FTE program for
  productivity and efficiency.
• Video conference.
• Site visit by client as well as by Sapala PM
  yearly once.

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Documentation

• Laboratory note books (LNBs) issued for all
  FFS and FTE project.
• SOP for writing LNBs Compliance is
  mandatory.
• Orderly upkeep of supporting information
  (Spectroscopic data and
• literature) in separate folder with
  appropriate identification.
• LNBs and supporting folder are audited
  regularly by QA / QC department for
• their compliance.
• Weekly / fortnightly updates to track
  progress.
• Structured QA / QC reports
• Project report is submitted upon completion
  details goals and suggested
• path, if any alteration and modifications in
  the same to complete the project.
• Highlights if any additional information or
  knowledge is generated.

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Advantage Sapala

• Rich experiences in drug discovery research
  and development
• Key managers have extensive research
  experience in Japan and other
• developed countries.
• Japanese project management coupled to Indian
  research teams.
• Full analytical capabilities for synthesis on
  site
• Customers satisfaction
• Quality Custom Synthesis / On-time delivery
• Timely communication in English (or Japanese)
• High information-security
• Affordable Cost
• Highest environmental and safety standards
• International ethical standards

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Project Life Cycle

• Sign Confidentiality Disclosure Agreement.
• Evaluate RFQ / RFP.
• Propose details of the approaches to the
  deliverables including quotation.
• Sign research / production agreement with
  clearly defined terms and conditions.
• Appoint a dedicated scientific project manager.
• Update weekly and biweekly to client after the
  initiation of the project.
• Communicate with regular teleconference or
  video conference.
• Deliver on time the deliverables to client.

All IPR generated during the project execution is
owned by the client.
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Contacts
USA Dr. Yogesh S. Sanghvi 2802 Crystal Ridge
RoadEncinitas, CA 92024 U.S.A. Phone
760.944.1541Fax [phone]cell
7603107539 Email yogeshss_at_sapalaorganics.com EU
Dr. Md. K. Nazeeruddin Station 6 Laboratory of
Photonics and Interfaces (LPI) Institute of
Chemical Science and Engineering Faculty of Basic
Science Ecole Polytechnique Federale de
Lausanne CH-1015 Lausanne Switzerland Tel 41 21
693 6124 Fax [phone] Email
s.nazeeruddin_at_heliochemicals.ch
Japan Dr. Masami Nakane 124-1 Miyukiyama
Tenpaku Nagoya Aichi 468-0075 Phone and Fax
81-52-836-6945 Email masami.nakane_at_sapalaorganics
.com India G. Sanjay Plot 146B 147,
Phase-II, IDA Mallapur, Uppal Mandal, Kapra
Muncipality, Hyderabad-500076 (A.P), India.
Mobile [phone] Fax [phone] Emai
lsanjayg_at_sapalaorganics.com
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Thank you.