Flow Volume Loop Resistance = P/flow FRC ours have normal

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Flow Volume Loop
Resistance ?P/flow
FRC
ours have normal circles or error bars or normal
curve
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Flow Volume Loop
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Flow Volume Loop
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Expiratory flow limitation - Choke point
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Resistance
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Volume effects on vasculature and airways
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Tethering
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Tests of flow limitation

• FEV1
• FEF 25-75
• FEV1/FVC

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Obstruction/Restriction
Normal Asthma COPD Restriction
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Lung Volumes
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Lung Volumes
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Measurement of FRC
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Overview of System
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Pulmonary Circulation
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Pulmonary Circulation
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Pulmonary Circulation

• 1. Gas exchange
• 2. Fluid exchange
• 3. Reservoir for LV
• 4. Nutrition
• 5. Filter

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Pulmonary circulation
collateral flow from systemic system
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Pulmonary Pressures

• 1. Absolute intravascular pressure
• 2. Transmural pressure
• 3. Driving pressure
• 4. Relation to pre-load

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Resistance in pulmonary vasculature
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Measurements
Pre-load
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Pulmonary artery catheter
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Cardiac output
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Regional flow
watch H2O to Hg
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Regional Flow
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WEST Zones
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WEST Zones
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Volume effects on vasculature
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Volume effects on vasculature
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Zones for real
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Hypoxic effects
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Fluid balance
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Starling relations
.

• Qf Kf (Pmv-Ppmv)-?(?mv-?pmv)

10-(-3) - .75(25-16) 13 - 7 6 mL
H2O/min/mm Hg/unit area
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Pulmonary Edema

• high vs low pressure

capillary pres membrane protein in alv
fluid repair
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Overview of System
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Oxygen Transport
Fe location of O2 binding Hgb 1/4 RBC
volume drop organelles 140
day T1/2 Hct Vol/Vol
O2 shift - ? color - cooximeter
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Blood
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Oxygen content
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Oxygen content

• CaO2 (0.003 PO2 ) (1.34xHgbxSat)

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Oxy-Hgb Saturation Curve
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Bohr Shift
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Fick Principle

• O2 use Flow x (O2 upstream - O2 downstream)

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Carbon Dioxide
H2O CO2 ? H HCO3-
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Haldane effect
1. CO2XHgbdeoxy 2. H better to Hgbdeoxy
??H2O CO2?H HCO3- to right
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